ArticleAlzheimer's & dementia. Behavior & socioeconomics of aging2025
Associations of Place-based Social Determinants of Health with Biomarkers of Alzheimer's Disease and Related Dementias.
Article in Alzheimer's & dementia. Behavior & socioeconomics of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Structural and social determinants of health shape the impact of neurodegeneration and cerebrovascular pathology on cognitive functioning in black adults.Social science & medicine (1982) · 2026Article
- Long-Term Industrial Emissions Exposure and Cognitive Impairment in Older U.S. Adults: A Longitudinal Cohort Study.Health science reports · 2026Article
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Contextualizing Blood-Based Biomarkers for Dementia Globally.Journal of neurochemistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Introduction: Relationships between place-based social determinants of health (SDoH) and Alzheimer's disease and related dementias biomarkers are emerging. Methods: Linear regressions examined associations of area deprivation index (ADI), social vulnerability index (SVI), and environmental justice index (EJI) with biomarkers among Healthy Brain Study participants (n=679), stratified by racialized groups. Neuroimaging biomarkers included cortical thickness, brain parenchymal volume, white matter hyperintensity volume, cerebral blood flow (CBF) and its variability in gray matter. Plasma biomarkers included glial fibrillary acidic protein (GFAP), amyloid-beta ratios, and phosphorylated-tau 181. Results: Place-based SDoH measures were higher in Black compared to White participants. Among Black participants, we found relationships between higher SVI and EJI with higher CBF variability, higher ADI with lower mean CBF, and higher ADI and SVI with lower cortical thickness. Discussion: Place-based SDoH may partially capture effects of structural racism on brain health and affirm the importance of structural interventions in addressing SDoH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.