ArticleNeuropsychiatric disease and treatment2026
Altered Habenula Resting-State Functional Connectivity and Spatial Associations with Neurotransmitter Receptor Distribution of Major Depressive Disorder with and without Anhedonia.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to examine functional connectivity (FC) alterations in patients with major depressive disorder (MDD), specifically comparing those with and without anhedonia. Methods: 24 MDD patients with anhedonia (MDD-WA), 17 MDD patients without anhedonia (MDD-WoA), and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI). Intrinsic brain function was assessed using resting-state FC and spatial associations with neurotransmitter receptor distribution analyses. The habenula (Hb) was selected as the region of interest (ROI), and the whole-brain FC of the Hb was compared across groups. Spatial correlations between inter-group FC differences and whole-brain neurotransmitter receptor/transporter expression templates, derived using the JuSpace tool, were analyzed. Additionally, FC values from differential brain regions were extracted and correlated with the scores on the clinical scale. Results: Compared to MDD-WoA patients, MDD-WA patients exhibited reduced FC between the Hb and the left middle frontal gyrus (MFG). Enhanced FC was observed between the Hb and bilateral putamen in MDD-WA patients compared to HCs. Additionally, in the MDD-WA group, changes in the Hb whole-brain FC demonstrated positive correlations with the spatial density distribution of specific neurotransmitter receptors and transporters. In contrast, MDD-WoA showed no significant Hb FC differences or neurotransmitter correlations compared to HCs. No significant correlations were found between the FC values of the intergroup-different brain regions and the total SHAPS-C, total HAMD-17, and all HAMD-17 factor scores (anxiety/somatization, weight loss, cognitive disturbance, retardation, and sleep disturbance). Conclusion: In patients with MDD-WA, FC between the habenula and bilateral putamen, as well as between the habenula and left MFG, was altered. Given that the putamen is a core component of the striatum, all these findings suggest that habenula-prefrontal-striatal dysconnectivity may represent an anhedonia-specific biomarker in MDD. The FC patterns between the habenula and bilateral putamen/left middle frontal gyrus, along with the related neurotransmitter profiles identified in this study, may serve as objective indicators for monitoring therapeutic efficacy in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.