ArticleFrontiers in nutrition2026
The heterogeneous nutritional status trajectory and its predictors in elderly patients undergoing lung cancer surgery: a prospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: The assessment and management of nutritional status are particularly important for reducing adverse outcomes in elderly patients undergoing lung cancer surgery. This study aimed to identify the heterogeneous nutritional status trajectory of elderly patients undergoing lung cancer surgery and analyze its predictors. Methods: A prospective cohort study was conducted in a tertiary cancer hospital in mainland China. The nutritional status of the participants was evaluated assessed on the day of admission, the day before discharge, and on the 1st, 3rd, and 6th month postoperatively. Data were analyzed using the latent class growth model, generalized linear model and logistic regression. Results: A total of 474 eligible elderly patients completed all follow-ups. Three distinct nutritional status trajectories were identified: "Severe Malnutrition-Rapid Improvement Group," "Moderate Malnutrition-Rapid Improvement Group," and "Persistent Low Malnutrition Risk Group." The "Severe Malnutrition-Rapid Improvement Group" and "Moderate Malnutrition-Rapid Improvement Group" had persistent severe and moderate malnutrition, respectively, from the day before discharge to 1 month postoperatively, and both constituted populations in urgent need of clinical intervention; additionally, their quality of life across multiple domains was significantly lower than that of the "Persistent Low Malnutrition Risk Group" at 6 months postoperatively ( Conclusion: The nutritional status trajectories of elderly patients undergoing lung cancer surgery are highly heterogeneous and affect postoperative quality of life. Early identification and management of high-risk factors can reduce the risk of malnutrition, improve quality of life, and decrease the occurrence of adverse outcomes.
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