ArticleFrontiers in neurology
Association between systemic inflammation biomarkers and outcomes in patients with aneurysmal subarachnoid hemorrhage.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Inflammation, coagulation, and nutritional reserves refine 90-day prognostic stratification after ruptured intracranial aneurysm repair.Frontiers in nutrition · 2026Article
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Authors and funding
15 authors.
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Abstract
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating condition that is associated with cerebral and systemic inflammation. C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLr) are easily available biomarkers of systemic inflammation. Therefore, we aimed to assess the impact of elevated CRP and NLr on aSAH outcomes. This retrospective, single-center study included adult patients admitted with aSAH to the intensive care unit (ICU) from January 2007 to December 2023. We recorded serum CRP and NLr levels during the first 7 days of ICU stay. An unfavorable neurological outcome at 3 months was defined as a Glasgow Outcome Scale (GOS) score of 1-3. A total of 547 patients were included in the study; 250 (45.7%) experienced unfavorable outcomes (UOs), and 140 (25.6%) developed delayed cerebral ischemia (DCI). Patients with unfavorable outcomes had higher levels of CRP from days 2 to 7 after SAH (
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