ArticleJournal of advanced veterinary and animal research2025
Novel mutation sites in the
Article in Journal of advanced veterinary and animal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Buffalo ( Materials and Methods: Four Toraya buffaloes (1 white, 2 striped, and 1 black) and two black Murrah buffaloes were used as experimental animals. In addition, seven Results: A total of five nucleotide variation sites were identified in the experimental animals, including three novel mutations (c.26M, c.49Y, and c.50R) and two previously reported mutations (c.170R and c.244K). Among these, c.50R was identified as a synonymous mutation, while the remaining mutations were non-synonymous and predicted to affect the amino acid sequence of the MC1Rprotein. Notably, all three novel mutation sites were consistently present in all studied Toraya and Murrah buffaloes, suggesting shared genetic variants across phenotypically distinct populations. Structural prediction analysis indicated that these mutations could potentially alter the conformation and function of the MC1R protein. Conclusion: The identification of three novel mutations in the
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