ArticleFrontiers in public health2026
Associations of physical fitness and choice reaction time with chronic fatigue in working-age adults: a population-based study.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic fatigue is prevalent among working-age adults and has been linked to reduced physical capacity and impaired cognitive performance. While physical fitness is considered protective against fatigue-related dysfunction, few large-scale studies have examined how multidimensional fitness profiles relate simultaneously to chronic fatigue status and functional cognitive-motor outcomes. Clarifying these associations may improve risk stratification and functional assessment in occupational health settings. Methods: In this cross-sectional study, 3,025 adults from the National Physical Fitness Health Test were evaluated. Chronic fatigue was defined using a standardized questionnaire cutoff. Physical fitness was assessed using an eight-component standardized battery and summarized as a composite Physical Fitness Index. Choice reaction time (CRT) was measured as a functional cognitive outcome. Multivariable logistic and linear regression models examined independent associations, adjusting for demographic, occupational, and anthropometric covariates. Sex-stratified ROC analyses evaluated discriminatory performance. Results: Chronic fatigue was identified in 5.45% of participants and varied significantly across occupational groups. Individuals with chronic fatigue demonstrated slower CRT and lower overall physical fitness (both Conclusions: Chronic fatigue is associated with clinically meaningful slowing of cognitive-motor response and reduced multidimensional fitness. Overall fitness independently relates to both fatigue risk and reaction performance, underscoring the importance of maintaining physical fitness to mitigate functional impairment in working-age populations.
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