ArticleReviews in cardiovascular medicine2026
Percutaneous Closure of Patent Foramen Ovale is Associated With Improvement of Migraine.
Article in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patent foramen ovale (PFO) is the most common congenital heart defect and has been linked to migraines; however, the relationship between PFO and migraine remains controversial. This study aimed to evaluate whether percutaneous PFO closure alleviates migraines and explore the association between PFO and migraine. Methods: Data from 5581 inpatients with PFO were collected between 2015 and 2020. A total of 71 stroke-free adults with PFO (45 with closure and 26 without) were included. Self-reported migraine history, frequency, and severity (0-10) were assessed. Outcomes were compared between patients with and without PFO closure, and logistic regression was used to examine the relationship between PFO closure and migraine improvement. Results: PFO closure significantly reduced migraine frequency and severity, with greater improvements observed after 2 years ( Conclusion: Percutaneous PFO closure significantly improved migraines by reducing both frequency and severity, supporting a potential association between PFO and migraine.
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