ArticleAngewandte Chemie (International ed. in English)2026
The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Uncover the strength of polyhedral dicarbaboranes as the next generation of superbases in organocatalysis.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Polyhedral carboranes are highly biologically stable, non-toxic clusters. Whereas they are typically encountered in anionic or neutral forms, positively charged species have only recently been discovered. The in vitro antiproliferative effects of selected carboranes were assessed using a panel of human cancer cell lines, and off-target toxicity was evaluated at normal cell lines. The results demonstrated significant anticancer activity and a favorable resistance factor (RF ≈ 1) for monocationic carborane o-2a, surpassing the effects of doxorubicin and cisplatin. In pursuit of even more efficient substrates, the first dicationic polyhedral boranes were synthesized. These water-stable dications exhibit a reversible closo-/nido- cage opening, triggered either by a strong base (DMAP) or by a combination of triethylamine and molecular hydrogen, and reversed upon the addition of acid. The former transformation proceeds without a redox change, while the latter involves a H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.