Evidence map›Paper›PMID 41923617›Full record

ArticleNeuron2026

TMEM145 is a principal component of outer hair cell stereocilia.

Dennis Derstroff, Marisa Flook, Antonia Löhnes, Paulina Kreye, Sherylanne Newton, Vijay Renigunta, Saskia Hanemaaijer, Carlos Aguilar, Jeffrey R Holt, Michael R Bowl and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dennis DerstroffDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany; Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany.
Marisa FlookUCL Ear Institute, University College London, London, UK.
Antonia LöhnesDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany.
Paulina KreyeDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany.
Sherylanne NewtonUCL Ear Institute, University College London, London, UK; Mammalian Genetics Unit, MRC Harwell, Harwell, UK.
Vijay ReniguntaDepartment of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany.
Saskia HanemaaijerMammalian Genetics Unit, MRC Harwell, Harwell, UK.
Carlos AguilarUCL Ear Institute, University College London, London, UK; Mammalian Genetics Unit, MRC Harwell, Harwell, UK.
Jeffrey R HoltDepartments of Otolaryngology and Neurology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA 02115, USA.
Michael R BowlUCL Ear Institute, University College London, London, UK; Mammalian Genetics Unit, MRC Harwell, Harwell, UK. Electronic address: m.bowl@ucl.ac.uk.
Dominik OliverDepartment of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany.
Katrin ReimannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany. Electronic address: katrin.reimann@staff.uni-marburg.de.

Funding

TMC gene function in sensory hair cellsR01DC013521 · NIDCD · BOSTON CHILDREN'S HOSPITAL · PI JEFFREY R HOLT · 2013 to 2026
$6.0M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentR01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HERTZANO, RONNA · 2015 to 2022
$3.6M
NIDCD NIH HHS R01 DC013521NIDCD NIH HHS R01 DC013817
6 · The paper itself

Abstract

The exquisite acuity of mammalian hearing relies on cochlear amplification provided by sensory outer hair cells (OHCs), downstream of mechanoelectrical transduction of sound. In OHCs, transduction is initiated by deflection of stereocilia conveyed through tethering to the tectorial membrane (TM) via an incompletely characterized protein complex, the TM attachment crowns (TM-ACs). We identify Tmem145, a G protein-coupled receptor (GPCR)-related "Golgi-dynamics-domain-seven-transmembrane (GOST)" protein, as the core element of TM-ACs. Tmem145 localized to the tips of the tallest row of stereocilia, precisely matching the localization of previously known components of TM-ACs, tubby, and stereocilin. Genetic ablation in mice resulted in loss of tubby and stereocilin from OHC stereocilia, disconnection of the hair bundle from the TM, and profound hearing loss with a lack of cochlear amplification. Tmem145 binds cytosolic tubby and anchors secreted stereocilin, likely through its extracellular Golgi-like domain. This architecture suggests a general role of Tmem145-related proteins as organizers of transmembrane anchor complexes.

Indexed as

Hair Cells, Auditory, OuterMembrane ProteinsStereociliaAnimalsHearing LossMiceMice, KnockoutTectorial MembraneMembrane ProteinsGOST proteinshearing lossouter hair cellsstereociliastereocilintectorial membrane attachment crownsTmem145tubby

Identifiers

PMID41923617
PMCPMC13048287

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.