ArticleNeurogastroenterology and motility2026
Pyloric Metrics and Distensibility Plateau by Functional Luminal Imaging Probe in Pediatric Patients: A Pilot Study.
Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsPyloric dysfunction contributes to chronic nausea, vomiting, and abdominal pain in adults and children. The Functional Luminal Imaging Probe (FLIP) has been used in adults to characterize pyloric distensibility as a marker of muscular hypertonicity and to predict symptomatic improvement to intrapyloric botulinum toxin injection (IPBI). FLIP parameters that identify pyloric dysfunction in children are unknown. In this retrospective cohort study, we aimed to characterize the relationship of pyloric FLIP parameters to clinical symptoms, gastric emptying (GE), and antroduodenal manometry (ADM) findings in pediatric patients. Secondarily, we aimed to assess FLIP metrics as related to the subjective response to IPBI.
methodsChart review was performed for patients undergoing pyloric FLIP for refractory upper gastrointestinal symptoms at Lurie Children's Hospital. FLIP parameters were compared to symptoms, demographics, medical history, GE, ADM findings, and documented response to IPBI. The presence of a distensibility plateau (DP) was assessed.
resultsNinety-nine patients underwent pyloric FLIP and 74 were treated with IPBI. Pyloric distensibility index (pDI) correlated with age and biological gender. Patients with chronic nausea, early satiety, concurrent pain disorders, joint hypermobility, and orthostatic intolerance demonstrated higher pDI compared to other symptoms. While pDI did not correlate with GE, it was lower in patients with normal fasting patterns on ADM and higher in IPBI responders. Nearly half of patients demonstrated a DP for which pDI was significantly higher in IPBI responders.
conclusionsThis pilot study supports pyloric dysfunction as a mechanism underlying chronic upper gastrointestinal symptoms and would support prospective investigation of pyloric FLIP metrics in pediatrics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.