ArticleJournal of clinical laboratory analysis2026
Large-Scale Evaluation of Traditional Chinese Medicines Reveals Potential PPARγ Modulators for Type 2 Diabetes Management.
Article in Journal of clinical laboratory analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundPeroxisome proliferator-activated receptor-gamma (PPARγ) is a pivotal nuclear receptor regulating glucose and lipid homeostasis, making it a primary therapeutic target for type 2 diabetes mellitus (T2DM). Despite the therapeutic potential of Traditional Chinese Medicine (TCM), a systematic, large-scale evaluation of its modulatory effects on PPARγ remains insufficient.
methodsWe developed a high-throughput screening platform utilizing a pGL4.17-PPARγ promoter-luciferase reporter system in 293 T cells. A library of 639 TCM samples (345 single formulas, SF; 294 multiple formulas, MF) was evaluated. Leading candidates were validated through RT-qPCR, Western blotting, and ELISA to assess PPARγ mRNA expression and protein abundance.
resultsScreening identified 139 TCMs that enhanced PPARγ activity, with 47 SF and 2 MF achieving an effective rate (ER) exceeding 60%. Notably, 25 of these are novel candidates for T2D, while 24 align with previous reports. Specifically, Astragali Radix (S241) and Puerariae Thomsonii Radix (S258) were identified as potent inducers, significantly upregulating PPARγ at both transcriptional and translational levels. Conversely, 55 samples, including Gymnema sylvestre (S169) and Paris polyphylla (S3), exhibited robust inhibitory effects, reducing ER by -52% to -99%.
conclusionsThis study identified 45 novel TCM candidates for T2D management. While several TCMs demonstrated PPARγ inhibition despite their traditional use for diabetic symptom alleviation, our findings suggest that a comprehensive evaluation is essential to balance their immediate clinical benefits with long-term metabolic management and potential side effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.