ArticleCNS neuroscience & therapeutics2026
GABAergic Neuron Activation in the RMTg-VTA Pathway Modulates Dopaminergic Neuron Excitability and Social Stress Susceptibility in Male Mice.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic social stress is a significant risk factor for neuropsychiatric disorders such as anxiety and depression, with the ventral tegmental area (VTA) playing a pivotal role. Although chronic social defeat stress (CSDS) induces adaptations in VTA dopaminergic (DA) neurons, the role of GABAergic modulation in regulating DA neuron excitability and related behaviors remains unclear.
methodsIn this study, we investigated the effects of GABA
resultsOur results show that susceptible mice exhibit enhanced spontaneous firing of VTA DA neurons and increased GABA
conclusionThese findings suggest that activation of RMTg GABAergic neurons projecting to VTA effectively reduces DA neuron excitability in the VTA and plays a critical role in the modulation of stress-induced behavioral deficits, offering a potential therapeutic target for neuropsychiatric disorders.
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