Evidence map›Paper›PMID 41923362›Full record

ArticleHemodialysis international. International Symposium on Home Hemodialysis2026

Effect of Hemodiafiltration and Hemodialysis on Postoperative Mortality in Patients With Kidney Failure.

Dharmenaan Palamuthusingam, Carmel M Hawley, Elaine M Pascoe, David Wayne Johnson, Martin Wolley, Stephen McDonald, Neil Boudville, Matthew D Jose, Girish Talaulikar, Nicholas B Cross and 1 more

Abstract read
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Article in Hemodialysis international. International Symposium on Home Hemodialysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Dharmenaan PalamuthusingamMetro North Kidney Health Service, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Carmel M HawleyFaculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.
Elaine M PascoeCentre for Health Services Research, University of Queensland, St Lucia, Queensland, Australia.
David Wayne JohnsonMetro South Kidney and Transplant Services, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Martin WolleyMetro North Kidney Health Service, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Stephen McDonaldCentral Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Neil BoudvilleFaculty of Medicine, University of Western Australia, Perth, Western Australia, Australia.
Matthew D JoseDepartment of Nephrology, Royal Hobart Hospital, Hobart, Tasmania, Australia.
Girish TalaulikarRenal Services, ACT Health, Canberra, Australians Capital Territory, Australia.ORCID https://orcid.org/0000-0001-9540-2253
Nicholas B CrossDepartment of Nephrology, Te Whatu Ora Waitaha Canterbury, Christchurch Hospital, Christchurch, New Zealand.
Magid FahimFaculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.

Funding

Royal Australasian College of Physicians
6 · The paper itself

Abstract

background and hypothesisPatients receiving chronic dialysis have increased risks of postoperative mortality and morbidity. Studies have suggested that patients receving hemodiafiltration (HDF) compared to hemodialysis (HD) may benefit from improved cardiovascular health, reduced infections and better overall survival. This study aimed to determine if patients receving HDF had improved postoperative outcomes after elective surgery compared to patients receiving HD.

methodsBi-national population cohort study evaluated all incident and prevalent patients receiving chronic hemodialysis in Australia and New Zealand. Surgeries included upper gastrointestinal, anorectal, hernia surgery, cholecystectomy and appendectomy. The primary outcome was 30-day all-cause mortality. Secondary outcomes included cardiovascular and infective outcomes. As there was potential for data to be correlated with multiple surgeries clustered at the patient and centre level, a multi-level mixed effects logistic regression model was used, with patient level covariates as fixed effects and dialysis centre as random intercepts, whereby patients were nested within centres.

resultsDuring the study period, there were 1750 surgeries in 1669 patients, of which 416 (23.8%) were receiving HDF. The median age was similar in both groups, as was the prevalence of comorbidities. Patients receiving HDF had received dialysis for a shorter period (0.9 vs. 2.3 years, p < 0.001). The 30-day mortality rate was lower in patients receiving HDF than in those receiving HD (1.9 vs. 3.3%, p < 0.005). Using multi-level mixed effects logistic regression, HDF was not associated with reduced mortality odds (OR 0.84, 95% CI 0.37-1.93) compared to patients receiving HD. Patients on HDF experienced a lower rate of a composite of infections (5.5 vs. 9.8%, p = 0.012), and required less blood transfusions (7.7 vs. 12.4%, p = 0.009). The occurrence of cardiovascular complications was not significantly different between the two groups (1.4 vs. 2.3%, p = 0.280).

conclusionsThe use of HDF was not associated with lower postoperative mortality odds but lower rates of infective complications compared to HD were observed.

Indexed as

HemodiafiltrationKidney Failure, ChronicPostoperative ComplicationsRenal DialysisAgedAustraliaCohort StudiesFemaleHumansMaleMiddle AgedNew Zealandabdominal surgerycardiovascularchronic dialysisgeneral surgeryhemodiafiltrationhemodialysisinfectionkidney failurepostoperative mortality

Identifiers

PMID41923362
PMCPMC13350432

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.