ReviewJournal of translational medicine2026
Exercise-induced muscle exosomes: microRNA cargo as regulators of cardiovascular remodeling and disease progression.
Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise-mediated extracellular vesicle-derived non-coding RNAs and cardiovascular protection: mechanistic insights and bibliometric analysis.Frontiers in physiology · 2026Pooled it
- mBiomolecules · 2026Review
- Cardiac biomarkers in athletes and active individuals: a clinical review of exercise-induced elevations and diagnostic interpretation.Frontiers in physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular diseases (CVD) are a primary cause of global morbidity and mortality, with incomplete understanding of how lifestyle factors like exercise provide protection. Skeletal muscle functions as a secretory organ, releasing exosomes containing microRNAs (miRNAs) that facilitate intercellular communication and influence inflammation, angiogenesis, and cardiac remodeling.
methodsThis review synthesizes recent literature on exercise-induced, muscle-derived exosomal miRNAs in cardiovascular biology. It emphasizes key miRNAs (miR-1, miR-133a/b, miR-206, miR-486) modulated by physical activity, their roles in endothelial function, myocardial repair, and vascular adaptation, as well as underlying cellular and molecular mechanisms and biomarker potential. Insights are integrated from molecular biology, exercise physiology, and cardiovascular research.
resultsExercise dynamically alters exosomal miRNAs, with high-intensity interval training (HIIT) inducing a 2- to 3-fold increase in circulating exosomal miR-133a, which reduces cardiac fibrosis by targeting connective tissue growth factor (CTGF). These miRNAs mediate protective effects on endothelial function, myocardial repair, and vascular adaptation, positioning them as biomarkers of cardiovascular health.
conclusionsExosomal miRNAs serve as key mediators of exercise-induced systemic adaptations and hold promise as targets for precision diagnostics and therapeutic interventions in CVD. CLINICAL TRIAL NUMBER: Not applicable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.