Evidence map›Paper›PMID 41923201›Full record

ArticleBMC geriatrics2026

Cognitive status and associated risk factors in high-risk older adults of China: a population-based cross-sectional study.

Jindong Ding Petersen, Feng Chen, Kun Zhang, Yong You, Huijun Wei, Liangyan Yuan, Peng Lu, Bingbing Zheng, Chen Liu, Zhanjun Zhang and 5 more

Abstract read
In one paragraph

Article in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jindong Ding Petersen *School of Public Health, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China.
Feng Chen *Department of Radiology, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China.
Kun Zhang *Geriatric Center, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China.
Yong YouSchool of Public Health, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China.
Huijun WeiGeriatric Center, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China.
Liangyan YuanGeriatric Center, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China.
Peng LuState Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University; Beijing Aging Brain Rejuvenation Initiative (BABRI) Centre, Beijing Normal University, Beijing, China.
Bingbing ZhengSchool of Public Health, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China.
Chen LiuState Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University; Beijing Aging Brain Rejuvenation Initiative (BABRI) Centre, Beijing Normal University, Beijing, China.
Zhanjun ZhangState Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University; Beijing Aging Brain Rejuvenation Initiative (BABRI) Centre, Beijing Normal University, Beijing, China.
Jens SøndergaardResearch Unit for General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Frans Boch WaldorffSection of General Practice, Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Wenting CaoSchool of Public Health, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China. caowenting@hainmc.edu.cn.
He LiBeijing Aging Brain Rejuvenation Initiative (BABRI) Centre, Beijing Normal University; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. her2003@163.com.
Tao LiuDepartment of Neurology, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospital), Haikou, China. neurologyhopkins@hainmc.edu.cn.

Funding

Hainan Medical University Leading Talent Scientific Research Initiation Project Fund No. XRC2022005Key Science and Technology Project of Hainan Province ZDYF2023SHFZ096Key Science and Technology Project of Hainan Province ZDYF2024SHFZ058Key Science and Technology Project of Hainan Province ZDYF2024SHFZ064National Natural Science Foundation of China 82160327National Natural Science Foundation of China 82271977National Natural Science Foundation of China 82360673
6 · The paper itself

Abstract

backgroundOlder adults at high-risk conditions are particular vulnerable to cognitive impairment; however, population-based assessments targeting this group remain limited. To exam cognitive status and associated risk factors in high-risk older adults in China.

methodsThis population-based cross-sectional study was conducted across Hainan Province comprising adults aged ≥ 60 years with at least one high-risk condition: physical activity limitations, disability, stroke history, mental health symptoms, or subjective memory concerns, through stratified regional sampling. Pre-mild cognitive impairment (Pre-MCI) and MCI were assessed using the validated BABRI-brain health system. Demographic and health-related data collected from registries and self-reports. The prevalence rates of Pre-MCI and MCI were calculated, and multivariable logistic regression was applied to identify risk factors.

resultsAmong 228,087 participants (mean age 73.6 ± 8.6 years; 57.6% female; 67.1% with primary education or less), the prevalence of Pre-MCI and MCI was 51.4% and 32.0%, respectively. Significant risk factors for cognitive outcomes included older age (OR range for Pre-MCI: 1.27 [1.24–1.30] to 3.09 [2.77–3.45]; for MCI: 1.04 [1.01–1.07] to 4.28 [3.84–4.78]), unmarried status (OR 1.07 [1.03–1.12] for Pre-MCI; 1.45 [1.39–1.52] for MCI), lower education (OR range for Pre-MCI: 1.37 [1.32–1.41] to 3.74 [3.59–3.89]; for MCI: 1.61 [1.54–1.68] to 6.92 [6.60–7.25]), occupation as farmer/housemaker (OR 1.37 [1.31–1.43] for Pre-MCI; 1.59 [1.51–1.67] for MCI), and residence in medium GDP regions (OR 1.74 [1.66–1.82] for Pre-MCI; 1.38 [1.32–1.45] for MCI). Additional risk factors included hearing impairment, cerebral hemorrhage, family dementia history, and hypertension. Sex-specific differences were observed.

conclusionThe high prevalence of cognitive impairment in high-risk older adults highlights the need for tailored public health strategies. Particular attention should be given to those who are unmarried, with lower education, hearing impairment, and hypertension.

Indexed as

CognitionCognitive DysfunctionPopulation SurveillanceAgedAged, 80 and overChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsCognitive impairmentMild cognitive impairmentOlder adultsPopulation-basedPrevalence

Identifiers

PMID41923201
PMCPMC13185332

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