Evidence map›Paper›PMID 41923199›Full record

ArticleMolecular cancer2026

Modeling pediatric low-grade glioma heterogeneity using human forebrain organoids.

Gloria Leva, Lucia Santomaso, Matteo Gianesello, Sara Patrizi, Federica Ress, Federico Cocchini, Celeste Antonacci, Francesca Gianno, Luana Abballe, Chiara Lago and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Gloria Leva *Department CIBIO, University of Trento, Trento, Italy.
Lucia Santomaso *Department CIBIO, University of Trento, Trento, Italy.
Matteo GianeselloDepartment CIBIO, University of Trento, Trento, Italy.
Sara PatriziOnco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Federica RessDepartment CIBIO, University of Trento, Trento, Italy.
Federico CocchiniDepartment CIBIO, University of Trento, Trento, Italy.
Celeste AntonacciOnco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Francesca GiannoDepartment of Radiological, Oncological and Anatomo Pathological Sciences, Sapienza University, Rome, Italy and IRCCS Neuromed, Pozzilli, Italy.
Luana AbballeOnco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Chiara LagoDepartment CIBIO, University of Trento, Trento, Italy.
Noemi PozzaDepartment CIBIO, University of Trento, Trento, Italy.
Gabriele TrentiniDepartment CIBIO, University of Trento, Trento, Italy.
Marina CardanoDepartment CIBIO, University of Trento, Trento, Italy.
Simone MinasiDepartment of Radiological, Oncological and Anatomo Pathological Sciences, Sapienza University, Rome, Italy and IRCCS Neuromed, Pozzilli, Italy.
Francesca Romana ButtarelliDepartment of Radiological, Oncological and Anatomo Pathological Sciences, Sapienza University, Rome, Italy and IRCCS Neuromed, Pozzilli, Italy.
Manila AntonelliDepartment of Radiological, Oncological and Anatomo Pathological Sciences, Sapienza University, Rome, Italy and IRCCS Neuromed, Pozzilli, Italy.
Davide PerniciDepartment CIBIO, University of Trento, Trento, Italy.
Linda PetrucciDepartment CIBIO, University of Trento, Trento, Italy.
Francesco AntonicaDepartment CIBIO, University of Trento, Trento, Italy.
Emma BusarelloDepartment CIBIO, University of Trento, Trento, Italy.
Martina IannuzziDepartment of Neuroscience, SISSA, Trieste, Italy.
Alessia SoldanoDepartment of Neuroscience, SISSA, Trieste, Italy.
Toma TebaldiDepartment CIBIO, University of Trento, Trento, Italy.
Evelina Miele *Onco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. evelina.miele@opbg.net.
Elisabetta Ferretti *Department of Experimental Medicine, Sapienza University, Rome, Italy. elisabetta.ferretti@uniroma1.it.
Luca Tiberi *Department CIBIO, University of Trento, Trento, Italy. elisabetta.ferretti@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric low-grade gliomas (pLGGs) are the most common type of brain tumors in children, characterized by their typically slow growth and oncogene-induced senescence. Preclinical models provide the opportunity to investigate the effects of various treatments in a controlled setting before they are tested in human patients; however, reliable models for pLGGs are limited. Here we developed two organoid models for pLGGs, which, after engraftment into mice, exhibited low-grade features. Furthermore, the genome-wide DNA methylation and RNA profiles of the organoids demonstrated closer similarity to low-grade glioma entities compared to high-grade counterparts. Additionally, pLGG organoid-derived cells align with oligodendrocyte-like, astrocyte-like and MAPK signature clusters seen in patient tumors, indicating that the organoids generate a heterogeneous population of cancer cells, where cellular diversity may influence disease progression and treatment response.

Indexed as

Brain NeoplasmsGliomaOrganoidsProsencephalonAnimalsChildDNA MethylationHumansMiceNeoplasm Grading

Identifiers

PMID41923199
PMCPMC13192117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.