SynthesisBMC medical genomics2026
The association of periodontitis with telomere length: a meta-analysis.
Synthesis in BMC medical genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTelomere length (TL) is a biomarker of biological aging and has been linked to various health outcomes; however, its relationship with periodontitis remains inconsistent. This meta-analysis aimed to evaluate the association between periodontitis and TL.
methodsPubMed, Scopus, Medline, and Embase databases were searched for relevant studies published until August 2025. The differences in mean TL between those with and without periodontitis were measured using standardized mean difference (SMD) with 95% confidence intervals (CIs), while standardized beta coefficients (β) and their 95% CIs were applied to assess the strength of the association using a random effects model.
resultsTen observational studies including 22,625 participants were analyzed. The overall results indicated no significant difference in mean TL between individuals with and without periodontitis (SMD = -0.03, 95% CI = -0.09 to 0.03). Additionally, no significant association was observed between periodontitis and TL (β = -0.001, 95% CI = -0.01 to 0.01). Subgroup analysis revealed that patients under 50 years old (SMD = -0.25, 95% CI = -0.41 to -0.09) and Asian patients (SMD = -0.44, 95% CI = -0.82 to -0.06) had significantly shorter TL compared to those without periodontitis. Additionally, periodontitis was significantly inversely associated with TL in these groups (age < 50: β = -0.07, 95% CI = -0.11 to -0.03; Asians: β = -0.20, 95% CI = -0.38 to -0.03).
conclusionPeriodontitis may be linked to shorter TL, indicating that TL could potentially serve as a biomarker for periodontal health.
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