ArticleEndocrine2026
Construction and Validation of a Simplified Bone Age Assessment Method Based on Three Key Bones from the TW3 system.
Article in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe Tanner-Whitehouse 3 (TW3) method is a widely used standard for bone age (BA) assessment. Although the TW3-China (TW3-C) version was developed specifically for the Chinese population, its complexity hinders routine clinical use.
objectivesTo construct a simplified TW3-based BA assessment method using only three key bones in order to assist pediatricians in quickly assessing BA in Chinese children.
methodsA total of 2,622 eligible healthy children aged 6–18 years were selected from a population-based cross-sectional study in Beijing (2022–2023). Left-hand wrist radiographs were collected from the participants. The TW3-C-RUS assessment of 13 bones served as the conventional reference for skeletal maturity score (SMS) and BA. Three key bones were selected by the strength of their Pearson correlation with chronological age. Three weighting protocols were designed, with the optimal weighting determined by the minimum deviation of SMS and BA from the conventional reference. Age-for-SMS percentile curves were established based on three key bones using the optimal weighting. An external validation involving 335 participants was conducted to further evaluate the agreement between the simplified and reference methods.
resultsThe “radius, ulna, and metacarpal I” exhibited the strongest correlation with age (r = 0.91, 0.88, and 0.90,) and were selected as key bones. Among the three weighting protocols evaluated, the high radius weighting protocol (radius 1/2, ulna 1/4, metacarpal I 1/4) achieved the highest correlation with the reference SMS (r = 0.99) and the lowest root mean square error (33.0). Age-for-SMS percentile curves were then constructed based on the “radius-ulna-metacarpal I” combination with the high radius weighting protocol. External validation demonstrated a mean BA difference of 0.02 years (95% CI: –0.03 to 0.07) between the simplified and standard TW3-C-RUS methods, with 94.9% of estimates differing by <1 year and 77.2% by <0.5 year.
conclusionThis simplified BA method demonstrated high consistency with the standard TW3-C-RUS method and may be practically useful to quick evaluate of BA in Chinese children.
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