Evidence map›Paper›PMID 41922825›Full record

ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Multifaceted regulation of immune cells in radiation-induced pulmonary fibrosis: from mechanistic insights to targeted therapies.

Li Shen, Wanrong Zhang, Yonghao Yang, Zhiqiang Du, Shiyan Fu, Feng Huang, Xiaoyu Yang, Juan Li, Yonghong Ran, Yuhui Hao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Li Shen *State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Wanrong Zhang *State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Yonghao Yang *State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Zhiqiang Du *State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Shiyan FuState Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Feng HuangState Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Xiaoyu YangState Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Juan LiState Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Yonghong RanState Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China. 1048765288@qq.com.
Yuhui HaoState Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China. yuhuihao@tmmu.edu.cn.

Funding

National Natural Science Foundation of China Youth Program 8240122280Scientific and Technological Research Program of Chongqing Municipal Education Commission KJZD-K202312801
6 · The paper itself

Abstract

backgroundRadiation induced pulmonary fibrosis (RIPF) is a life threatening and frequent complication that can occur after radiotherapy to thoracic cancers, and has a complicated pathogenesis and few treatment options. Recent data suggest that immune cells are the centerpiece of this mechanism, and constitute a complex system of regulation.

objectiveThis review systematically summarizes the dynamic roles and molecular mechanisms of key immune cells in RIPF initiation and progression, and reviews current advances in targeted immunotherapies.

methodsA comprehensive literature search was conducted in PubMed and Web of Science for studies on immune regulation and therapeutic strategies in RIPF.

resultsRIPF exhibits profound spatiotemporal heterogeneity, with immune cell subsets evolving dynamically from inflammation to fibrosis. Macrophages transcend the M1/M2 dichotomy, encompassing specialized subsets. Neutrophils promote fibrosis via NETosis and STAT3/NLRP3 pathways, while eosinophils switch from protective to pathogenic phenotypes. Beyond Th1/Th2 imbalance, Tregs and Th17 cells critically contribute to fibrosis. Emerging targeted strategies-including nanomaterials, natural compounds, and specific inhibitors-have shown promising preclinical results.

conclusionUnderstanding the spatiotemporally specific functions of immune cells is crucial for developing precision immunotherapies. Future research should focus on biomarker-guided combination strategies to transform RIPF into a preventable and manageable condition.

Indexed as

Pulmonary FibrosisRadiation PneumonitisAnimalsHumansImmunotherapyMacrophagesNeutrophilsImmune cellsMechanismRIPFTargeted therapy

Identifiers

PMID41922825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.