Evidence map›Paper›PMID 41922774›Full record

ArticleNature2026

Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair.

Wenlong Xia, Laura Morcom, Zhaoyang Xu, I-Ling Lu, Qing Wang, Kimberly K Hoi, Mingming Wei, Keying Zhu, Gregory Jordan, Xiao-Yan Tang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Wenlong XiaDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Laura MorcomDepartment of Paediatrics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6683-4356
Zhaoyang XuDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
I-Ling LuInstitute for Regenerative Medicine, University of California, San Francisco, San Francisco, CA, USA.
Qing WangDepartment of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Kimberly K HoiDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Mingming WeiDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Keying ZhuDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7500-1532
Gregory JordanDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
Xiao-Yan TangDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Julio Gonzalez-MayaDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Vanesa S MatteraDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Sophia M PanigrahiDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Riki KawaguchiDepartment of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2489-4825
Ben EmeryJungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0002-9132-3045
Santos J FrancoDepartment of Pediatrics, University of Colorado Anschutz School of Medicine, Aurora, CO, USA.
Daniel H GeschwindDepartment of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Brian PopkoDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9948-2553
David H RowitchDepartment of Paediatrics, University of Cambridge, Cambridge, UK. dhr25@cam.ac.uk.ORCID http://orcid.org/0000-0002-0079-0060
Stephen P J FancyDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. stephen.fancy@ucsf.edu.ORCID http://orcid.org/0000-0002-2818-8258

Funding

Regulation of Cellular Pathwaysin Human Brain DevelopmentP01NS083513 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 2014 to 2024
$12.6M
Neuronal responses to chronic demyelinationR01NS120981 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EMERY, BEN · 2021 to 2025
$2.1M
NINDS NIH HHS P01 NS083513NINDS NIH HHS R01 NS120981
6 · The paper itself

Abstract

During mammalian evolution, excitatory neurons in upper cortical layer 2 and layer 3 (L2/3) have shown a disproportionate expansion compared with other layers

Indexed as

Cerebral CortexDNA RepairHomeodomain ProteinsNeuronsNuclear ProteinsRepressor ProteinsActivating Transcription Factor 4AnimalsAtaxia Telangiectasia Mutated ProteinsDNA DamageFemaleMaleMicePhosphorylationRNA-Binding ProteinsTumor Suppressor Protein p53Activating Transcription Factor 4Ataxia Telangiectasia Mutated ProteinsAtf4 protein, mouseAtm protein, mouseHomeodomain ProteinsNuclear ProteinsRepressor ProteinsRNA-Binding ProteinsTumor Suppressor Protein p53

Identifiers

PMID41922774
PMCPMC13190340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.