ArticleNature2026
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- What the 'negative space' tells us about the immunology of multiple sclerosis.Nature reviews. Immunology · 2026Article
- ActivatableChemical science · 2026Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors.
Laura Morcom *Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6683-4356
Wenlong Xia *Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Zhaoyang XuCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Yashika AwasthiDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Celine GeywitzDivision of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0009-0008-1222-2627
Matthew O EllisUK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.
Tomas NoliDivision of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0009-0003-8740-3688
Amel ZuljiDivision of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5185-1898
Daniel YamamotoCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Gemma C GirdlerCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Li KaiDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Keying ZhuDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7500-1532
Mingming WeiDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Xiao-Yan TangDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Kimberly K HoiDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Julio Gonzalez-MayaDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Greg J DuncanDepartment of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.
Adrien M VaquieCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Diana Gold DiazCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Riki KawaguchiSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2489-4825
Erdong LiuDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Yu SunUK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5356-3048
Denny YangUK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.
Gregory D JordanCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
I-Ling LuThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
Staffan HolmqvistCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6709-6666
Theresa BartelsCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Katherine RidleyCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Jennifer Ja-Yoon ChoiDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Santos J FrancoDepartment of Pediatrics, Section of Developmental Biology, University of Colorado-Anschutz Medical Campus, Denver, CO, USA.
Eric J HuangDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5381-3801
Ben EmeryJungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0002-9132-3045
Daniel GeschwindDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2896-3450
Lucas SchirmerDivision of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0001-7142-4116
Gabriel BalmusUK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.
Brian PopkoDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9948-2553
Stephen P J FancyDivision of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. stephen.fancy@ucsf.edu.ORCID http://orcid.org/0000-0002-2818-8258
David H RowitchCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. david.rowitch@csmc.edu.ORCID http://orcid.org/0000-0002-0079-0060
Funding
Regulation of Cellular Pathwaysin Human Brain DevelopmentP01NS083513 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 2014 to 2024
$12.6MNeuronal responses to chronic demyelinationR01NS120981 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EMERY, BEN · 2021 to 2025
$2.1MNINDS NIH HHS P01 NS083513NINDS NIH HHS R01 NS120981
Abstract
Neurodegeneration shows regional and cell-type-specific patterns in ageing and disease
Indexed as
DNA DamageHomeodomain ProteinsNeuroinflammatory DiseasesNeuronsAnimalsCell DeathDisease Models, AnimalDNA Breaks, Double-StrandedDNA RepairFemaleHumansInterferon-gammaMaleMiceMultiple SclerosisReactive Oxygen SpeciesHomeodomain ProteinsInterferon-gammaReactive Oxygen Species
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.