Evidence map›Paper›PMID 41922770›Full record

ArticleNature2026

Deconstruction of a spino-brain-spinal cord circuit that drives chronic pain.

Qian Wang, Joo Han Lee, Gregory Nachtrab, Yuan Yuan, Lei Yuan, Wei Qi, Manuel A Mohr, Jing Xiong, Mark A Horowitz, Xiaoke Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Qian Wang *Department of Biology, Stanford University, Stanford, CA, USA.
Joo Han Lee *Department of Biology, Stanford University, Stanford, CA, USA.
Gregory Nachtrab *Department of Biology, Stanford University, Stanford, CA, USA.
Yuan YuanDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5400-2568
Lei YuanDepartment of Biology, Stanford University, Stanford, CA, USA.
Wei QiDepartment of Biology, Stanford University, Stanford, CA, USA.
Manuel A MohrDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5189-541X
Jing XiongDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Mark A HorowitzDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Xiaoke ChenDepartment of Biology, Stanford University, Stanford, CA, USA. xkchen@stanford.edu.ORCID http://orcid.org/0000-0001-9032-9093

Funding

Molecular tools for precise manipulation of defined synaptic connectionsR01MH135934 · NIMH · STANFORD UNIVERSITY · PI Xiaoke Chen, IVAN SOLTESZ · 2024 to 2026
$4.0M
Multi-modal profiling of spatially resolved cell types mediating opioid withdrawalR01DA059602 · NIDA · STANFORD UNIVERSITY · PI Bogdan Bintu, Xiaoke Chen · 2023 to 2026
$3.1M
Thalamic Circuits Underlying Opioid SeekingR01DA045664 · NIDA · STANFORD UNIVERSITY · PI CHEN, XIAOKE · 2018 to 2022
$2.3M
Thalamic Circuits for Prosocial Behaviors in MiceR01MH116904 · NIMH · STANFORD UNIVERSITY · PI CHEN, XIAOKE · 2019 to 2022
$1.8M
Rapid brain-wide optogenetic screening with a noninvasive, dynamically programmable in vivo light sourceRF1NS126076 · NINDS · STANFORD UNIVERSITY · PI BUTTS-PAULY, KIM, CHEN, XIAOKE · 2022 to 2022
$1.8M
Circuitry and Molecular Mechanisms for Descending Pain FacilitationR01NS129834 · NINDS · STANFORD UNIVERSITY · PI Xiaoke Chen · 2023 to 2026
$1.7M
Arousal circuitry and opiate-associated memoriesR01HL150566 · NHLBI · STANFORD UNIVERSITY · PI CHEN, XIAOKE, DE LECEA, LUIS · 2019 to 2019
$1.6M
NHLBI NIH HHS R01 HL150566NIDA NIH HHS R01 DA045664NIDA NIH HHS R01 DA059602NIMH NIH HHS R01 MH116904NIMH NIH HHS R01 MH135934NINDS NIH HHS R01 NS129834NINDS NIH HHS RF1 NS126076
6 · The paper itself

Abstract

Tissue inflammation or nerve injury at the periphery can cause chronic pain. Although the spinal-cord-projecting neurons in the rostral ventromedial medulla (RVM

Indexed as

BrainChronic PainNeural PathwaysSpinal CordAnimalsDisease Models, AnimalFemaleHyperalgesiaInflammationMaleMiceNeuralgiaNeuronsNociceptionReceptors, Opioid, muSomatosensory CortexReceptors, Opioid, mu

Identifiers

PMID41922770
PMCPMC13078944

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.