Evidence map›Paper›PMID 41922764›Full record

ArticleNature2026

Gene regulatory landscape dissected by single-cell four-omics sequencing.

Yujie Chen, Zhiyuan Liu, Heming Xu, Jiayu Liu, Mengxuan Wang, Yi Chi, Boyuan Liang, Menghan Liu, Yongli Peng, Hao Ge and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Single-cell four-omics with CHARM.Nature reviews. Genetics · 2026
    Article
  2. Review
  3. Decoding the regulatory genome: single-cell four-omics integration.Signal transduction and targeted therapy · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yujie Chen *Biomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China.
Zhiyuan Liu *Biomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China.
Heming XuBiomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China.
Jiayu LiuBiomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China.
Mengxuan WangBiomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China.
Yi ChiPeking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0009-0006-5967-751X
Boyuan LiangSchool of Life Sciences, Tsinghua University, Beijing, China.
Menghan LiuBiomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China.
Yongli PengBeijing International Center for Mathematical Research (BICMR), Peking University, Beijing, China.
Hao GeBiomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0003-0404-5268
Dong XingBiomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences, Peking University, Beijing, China. dxing@pku.edu.cn.ORCID http://orcid.org/0000-0002-8237-481X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular diversity is governed not only by the transcriptome but also by multiple layers of epigenomic regulation, including nucleosome occupancy, chromatin states and genome architecture

Indexed as

EpigenomicsGene Expression RegulationSingle-Cell AnalysisAnimalsCell CycleChromatinEnhancer Elements, GeneticEpigenesis, GeneticEpigenomeHistone CodeHistonesMachine LearningMiceMouse Embryonic Stem CellsNucleosomesPromoter Regions, GeneticChromatinHistonesNucleosomes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.