Evidence map›Paper›PMID 41922731›Full record

ArticleNPJ digital medicine2026

Artificial intelligence assisted colorectal lesion detection in private practices a randomized controlled study.

Thomas J Lux, Zita Saßmannshausen, Ioannis Kafetzis, Michael Banck, Adrian Krenzer, Daniel Fitting, Boban Sudarevic, Joel Troya, Wolfgang Boeck, Frank Passek and 8 more

Registry-linked trialAbstract read
In one paragraph

Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05006092 (Multicenter Evaluation Study of the CADe System ENDOMIND in Surveillance Endoscopy for Colorectal Cancer in German Outpatient Cohort), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05006092 nacompletednot on this map

Multicenter Evaluation Study of the CADe System ENDOMIND in Surveillance Endoscopy for Colorectal Cancer in German Outpatient Cohort

TypeinterventionalSponsorWuerzburg University HospitalRan2021 to 2022Enrolled1,149ConditionsSurveillance Endoscopy for Colorectal Cancer, Artificial Intelligence, Polyps of Colon, CADeArmsENDOMIND
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Thomas J Lux *Interventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Zita Saßmannshausen *Interventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Ioannis KafetzisInterventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Michael BanckInterventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Adrian KrenzerInterventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Daniel FittingInterventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Boban SudarevicInterventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Joel TroyaInterventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Wolfgang BoeckGastroenterological practice Dres. Boeck/Haegele, Ulm, Germany.
Frank PassekGastroenterological practice Bad Saulgau, Bad Saulgau, Germany.
Tobias HeubachGastroenterological practice Heubach-Begetopoulos, Waiblingen, Germany.
Benjamin SimonisGastroenterological practice Darmstadt, Darmstadt, Germany.
Franz J HeilGastroenterological practice Andernach, Andernach, Germany.
Leopold LudwigGastroenterological practice Dornstadt, Dornstadt, Germany.
Frank PuppeArtificial Intelligence and Knowledge Systems, Institute for Computer Science, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Wolfram G ZollerDepartment of Internal Medicine and Gastroenterology, Katharinenhospital, Stuttgart, Germany.
Alexander MeiningInterventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Alexander HannInterventional and Experimental Endoscopy (InExEn), Internal Medicine II, University Hospital Würzburg, Würzburg, Germany. hann_a@ukw.de.

Funding

Funding cluster Forum Gesundheitsstandort Baden-Württemberg 5-5409.0-001.01/15
6 · The paper itself

Abstract

Computer-aided colonoscopy (CAC) may improve polyp detection and characterization compared to traditional colonoscopy (TC). However, recent studies also reported no relevant effect on adenoma detection rate (ADR). This study evaluates the real-time polyp detection system EndoMind during screening and surveillance colonoscopy in a multicenter randomized controlled trial. From November 2021 to November 2022, 933 individuals undergoing colorectal cancer screening or post-polypectomy surveillance were recruited and randomized in five outpatient treating centers (10 examiners; >10 years of experience). 914 Patients were included in the intention to treat analysis (CAC:452, TC:462) and detected lesions were framed on the primary monitor in the CAC group. More than 94% of the examinations were screening or surveillance colonoscopies with overall similar patient characteristics. The ADR (CAC:34.5% vs TC:32.9%; p = 0.656) was not significantly different between the groups. The effect of CAC on ADR remains a controversial discussion. Diverging study setups and patient collectives complicate consistent comparisons. Future studies should focus on large-scale real-world populations. ClinicalTrials.gov:NCT05006092 (registered: 2021-08-06).

Identifiers

PMID41922731
PMCPMC13053717

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.