Article in EMBO molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Claudia CavadasCenter for Neuroscience and Cell Biology (CNC-UC), University of Coimbra, Coimbra, Portugal.ORCID 0000-0001-8020-9266
Scott EbertDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-6598-2629
Nathan K LeBrasseurDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.ORCID 0000-0002-2002-0418
Sundeep KhoslaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.ORCID 0000-0002-2936-4372
João F PassosDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.ORCID 0000-0001-8765-1890
Christopher M AdamsDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.
Paul D RobbinsMasonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-1068-7099
Diana JurkDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA. jurk.diana@mayo.edu.ORCID 0000-0003-4486-0857
Funding
Validation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5M
The role of sub-lethal mitochondrial apoptotic stress in cellular senescenceR01AG068048 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2020 to 2024
$2.2M
Investigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and agingR01AG082708 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.5M
Development of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUG3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2021 to 2022
$1.1M
Hevolution Foundation (HF) #A22001Hevolution Foundation (HF) P30DK084567HHS | NIH | National Institute on Aging (NIA) AG062413HHS | NIH | National Institute on Aging (NIA) AG068182HHS | NIH | National Institute on Aging (NIA) AG076041HHS | NIH | National Institute on Aging (NIA) AG079754HHS | NIH | National Institute on Aging (NIA) AG086085HHS | NIH | National Institute on Aging (NIA) AI172501HHS | NIH | National Institute on Aging (NIA) R01AG068048HHS | NIH | National Institute on Aging (NIA) R01AG82708NCI NIH HHS UG3 CA268103NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG082708NIA NIH HHS U19 AG056278
6 · The paper itself
Abstract
Cellular senescence drives aging and age-related dysfunction across multiple tissues, including the brain. Through a high-content, senescent cell-based phenotypic screen of a small panel of natural products, we identified tomatidine, an aglycone of tomatine found in tomatoes, as a previously unrecognized senotherapeutic agent. In senescent human brain microvascular endothelial cells and fibroblasts, tomatidine selectively suppressed SASP expression without affecting p16
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice. · full record | OpenQuestion