Evidence map›Paper›PMID 41922616›Full record

ArticleScientific reports2026

Diagnostic value of bone marrow smear for amyloid detection and its correlation with clinical features in systemic light-chain amyloidosis.

Jianhu Li, Zhijuan Chang, Qiusu Tang, Mengmeng Tang, Huafeng Wang, Shuqi Zhao, Xiangli Gao, Dan Shen, Ting Zhang, Yijing Zhu and 6 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Jianhu Li *Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Zhijuan Chang *Department of Clinical Laboratory, Third Sanatorium, Air Force Healthcare Center for Special Services, Hangzhou, China.
Qiusu TangDepartment of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Mengmeng TangDepartment of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Huafeng WangDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Shuqi ZhaoDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Xiangli GaoDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Dan ShenDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Ting ZhangDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Yijing ZhuDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Jixiang TongDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Shuchong YuanDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Yingqing XuDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Hongyan TongDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China. tonghongyan@zju.edu.cn.
Jie JinDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China. jiej0503@zju.edu.cn.
Min YangDepartment of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China. yangmin111111@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the diagnostic value of bone marrow smear in systemic light chain (AL) amyloidosis and to investigate the correlation between bone marrow amyloid deposition and clinical characteristics. A total of 252 patients with AL amyloidosis were enrolled, including 126 with positive bone marrow biopsies and 126 with negative biopsies. Bone marrow smear detected amyloid deposits in 121 of 252 patients (48.0%). Among the 126 patients with positive bone marrow biopsies, 121 (96.0%) had positive smears; among the 126 patients with negative biopsies, all 126 (100%) had negative smears. The overall concordance between smear and biopsy was 98.0% (247/252). In the AL group without concomitant plasma cell or B-cell disorders, bone marrow amyloid deposition was significantly associated with λ light chain type, lower hemoglobin levels, and elevated levels of ALP, GGT, β2-MG, and NT-proBNP, suggesting a correlation with impaired liver, kidney, and cardiac function. Survival analysis indicated that bone marrow amyloid deposition had no significant impact on prognosis. Bone marrow smear may serve as a rapid screening tool for AL amyloidosis, and its combination with biopsy could enhance diagnostic efficiency.

Indexed as

AmyloidBone MarrowImmunoglobulin Light-chain AmyloidosisAdultAgedAged, 80 and overBiopsyChinaFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesAmyloidBone marrow biopsyBone marrow smearCongo redSystemic light-chain amyloidosisWright–Giemsa

Identifiers

PMID41922616
PMCPMC13183959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.