Evidence map›Paper›PMID 41922599›Full record

ArticleCellular & molecular immunology2026

SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation.

Yushuang Sun, Shuqia Xu, Dongyu Wang, Shuiying Gao, Xiaowen Qi, Miao Jiang, Dan Jian, Yaqiong Li, Zhaoyan Jiang, Miao Zhen and 6 more

Abstract read
In one paragraph

Article in Cellular & molecular immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yushuang SunDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Shuqia XuDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Dongyu WangDepartment of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Shuiying GaoDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xiaowen QiDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Miao JiangDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Dan JianDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yaqiong LiDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhaoyan JiangDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Miao ZhenDepartment of Burns, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Peng WangDepartment of Burns, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Bin ShuDepartment of Burns, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Julin XieDepartment of Burns, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Demeng ChenCenter for Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Qing TangDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jingting LiDepartment of Plastic Surgery, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Lijt66@mail.sysu.edu.cn.ORCID 0000-0002-3576-0320

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82073469; 82273561; 82473557Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2023A1515010146; 2024A1515013194
6 · The paper itself

Abstract

Keratinocytes are increasingly recognized as central regulators of cutaneous immune responses and key contributors to maintaining immune homeostasis. However, whether and how epidermal stem and progenitor cells (EPSCs) actively suppress proinflammatory signaling pathways to prevent excessive inflammation and maintain epidermal immune quiescence remains unclear. Here, we generated a conditional knockout mouse model (K14-CreERT; Supt6

Indexed as

EpidermisFeedback, PhysiologicalHomeostasisInflammationNF-kappa BAnimalsKeratinocytesMiceMice, KnockoutPsoriasisSignal TransductionTranscription Factor RelAWnt Signaling PathwayWound HealingNF-kappa BTranscription Factor RelAEpidermal differentiationNF-κBp65Skin inflammationSPT6

Identifiers

PMID41922599
PMCPMC13129108

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.