A new aurodox-family compound from Streptomyces sp. HKIB0009: structure and antibacterial activity.

Xingtao Li, Yuxin Sun, Mimi Tian, Linfang Tang, Yuan Chen, Zikang Zhao, Mingming Cao, Lijun Chen

Abstract read

In one paragraph

Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xingtao LiSchool of Pharmaceutical Sciences and Yunnan Provincial Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.ORCID http://orcid.org/0009-0000-7419-6008

Yuxin SunState Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0009-0003-6094-760X

Mimi TianState Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0009-0009-1199-5449

Linfang TangState Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0009-0001-4500-1096

Yuan ChenState Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0009-0001-5465-6668

Zikang ZhaoState Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0009-0006-5060-850X

Mingming CaoState Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China. caomingming@mail.kib.ac.cn.ORCID http://orcid.org/0000-0003-1386-8717

Lijun ChenSchool of Pharmaceutical Sciences and Yunnan Provincial Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China. chenlijun1@kmmu.edu.cn.ORCID http://orcid.org/0009-0004-2926-4365

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22177050Yunnan Department of Science and Technology | Applied Basic Research Foundation of Yunnan Province (Yunnan Province Applied and Basic Research Foundation) 202301AT070323

6 · The paper itself

Abstract

A new aurodox-family compound named 2-methyl-10-hydroxy-A83016F (1) and the known aurodox (2) were isolated from the Streptomyces sp. HKIB0009; their structures were determined through comprehensive analysis of NMR and HRMS data. The antibacterial activities of these compounds against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus were evaluated using the broth microdilution method. The results showed that compound 1 exhibited weak antibacterial activity.

Indexed as

Anti-Bacterial AgentsStreptomycesBacillus subtilisEscherichia coliMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusAnti-Bacterial Agents

Identifiers

PMID41922565

DOI10.1038/s41429-026-00915-1

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.