Evidence map›Paper›PMID 41922542›Full record

ArticleCommunications medicine2026

Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth.

Paula-Dene C Nesbeth, Xiajie Lyu, Anne L Dunlop, Youran Tan, Dana Boyd Barr, Volha Yakimavets, Parinya Panuwet, Mengyuan Ren, Stephanie M Eick, Blake R Rushing and 6 more

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In one paragraph

Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Paula-Dene C NesbethGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-6186-6068
Xiajie LyuGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Anne L DunlopDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-5092-8136
Youran TanGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-9955-8324
Dana Boyd BarrGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Volha YakimavetsGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-8864-2408
Parinya PanuwetGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Mengyuan RenGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-3819-4181
Stephanie M EickGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Blake R RushingDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Susan L McRitchieNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
Susan SumnerDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
P Barry RyanGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-5579-4256
Elizabeth J CorwinSchool of Nursing, Columbia University, New York, NY, USA.
Dean P JonesSchool of Medicine, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2090-0677
Donghai LiangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. donghai.liang@emory.edu.ORCID http://orcid.org/0000-0001-7311-2298

Funding

The Impact of the Intrauterine and Early Childhood Environments on Neurocognitive and Metabolic Development in African American Youth: Focus on the Gut-Brain AxisUG3OD023318 · OD · EMORY UNIVERSITY · PI BRENNAN, PATRICIA A, DUNLOP, ANNE LANG · 2016 to 2024
$4.5M
Maintenance and Enhancement of the Atlanta African American Maternal-Child CohortU24ES029490 · NIEHS · EMORY UNIVERSITY · PI DUNLOP, ANNE LANG, JONES, DEAN PAUL · 2024 to 2025
$743k
NIEHS NIH HHS U24 ES029490NIH HHS UG3 OD023318
6 · The paper itself

Abstract

backgroundExposure to tobacco smoke during pregnancy is an established risk factor for early birth including early term birth (ETB) and preterm birth (PTB). However, the underlying molecular mechanisms are minimally understood. In this study, we aimed to characterize the newborn metabolomic associations with early pregnancy maternal tobacco exposure biomarkers and early birth in 269 mother-child pairs in the Atlanta African American Maternal-Child Cohort (2016-2020).

methodsEstablished tobacco exposure biomarkers, cotinine and trans-3'-hydroxycotinine (3HC), were measured in maternal urine samples collected between 8-14 weeks of gestation. Newborn dried blood spots were collected for high-resolution metabolomics profiling. Metabolome-wide association studies and pathway enrichment analyses were conducted to determine metabolomic signals and pathways associated with tobacco exposure biomarkers, ETB, and PTB.

resultsWe show that biopterin metabolism is a significantly enriched pathway for all exposures and outcomes. Both tobacco exposure biomarkers are associated with riboflavin metabolism. The metabolites riboflavin and 5-hydroxytryptophan are associated with all exposures and outcomes.

conclusionsTaken together, these findings demonstrate that the newborn metabolome is altered by prenatal tobacco exposure and that these alterations are associated with elevated risks of early birth. Furthermore, perturbation in biopterin metabolism is a potential mechanism linking maternal tobacco exposure to early birth.

Identifiers

PMID41922542
PMCPMC13230697

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.