Evidence map›Paper›PMID 41922316›Full record

ArticleSpinal cord series and cases2026

Improving hand function in chronic incomplete tetraplegia by high-PAS intervention with alternative equipment: a case report.

Anna Nätkynmäki, Macey Higdon, Janne Avela, Anastasia Shulga

Abstract readCase Reports
In one paragraph

Article in Spinal cord series and cases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna Nätkynmäki *Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID 0000-0002-2694-6182
Macey Higdon *Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID 0009-0004-7531-0270
Janne AvelaFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID 0000-0002-2775-9952
Anastasia ShulgaBioMag Laboratory, HUS Diagnostic Center, Helsinki University Hospital, University of Helsinki and Aalto University School of Science, Helsinki, Finland. anastasia.shulga@helsinki.fi.ORCID 0000-0003-0262-3570

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe reproducibility of a paired associative stimulation (high-PAS) protocol, shown to be beneficial for rehabilitation in incomplete spinal cord injury (SCI), was investigated in a different technical environment. Whereas previous studies relied on a specific technical setup for high-PAS, here the protocol was replicated using alternative devices. Differences in technical attributes could influence the replicability of specific output. As the necessary technology is available in many clinical and research settings, validating the protocol across device systems is important for broader implementation of high-PAS in SCI rehabilitation. In this case, a high-PAS protocol was administered over 6 consecutive weeks in a patient with severe chronic incomplete SCI. CASE PRESENTATION: A 32-year-old male with chronic C5 American Spinal Injury Association Impairment Scale C tetraplegia participated in this study. Three muscle-nerve pairs from both upper extremities each received 20-min high-PAS, administered 22 times over 6 weeks. The patient was assessed by an experienced physiotherapist before high-PAS, immediately after it, and 1 month after. The intervention improved muscle strength, hand function, and daily task performance in both upper extremities. DISCUSSION: This study sought to replicate high-PAS improvement of motor and functional scores in a patient with severe chronic incomplete SCI and demonstrated that the results can be successfully recapitulated by alternative devices. The improvement observed was consistent with previous studies and supports applicability in more versatile technical environments.

Indexed as

Electric Stimulation TherapyHandQuadriplegiaSpinal Cord InjuriesAdultChronic DiseaseHumansMale

Identifiers

PMID41922316
PMCPMC13043694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.