Evidence map›Paper›PMID 41921884›Full record

ArticleHeart rhythm2026

Ultrasound-guided parasternal tunneling during intermuscular subcutaneous implantable cardioverter-defibrillator implantation is associated with lower shock impedance and more favorable implant geometry.

Fabian Sanchis-Gomar, Leah Schloss, Alexander C Perino, Mohan N Viswanathan, Tina Baykaner, Roy M John, Albert J Rogers, Nitish Badhwar, Sanjiv M Narayan, Paul J Wang and 1 more

Abstract read
In one paragraph

Article in Heart rhythm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Fabian Sanchis-GomarDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California; Department of Health Sciences, University of Burgos, Burgos, Spain.
Leah SchlossDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
Alexander C PerinoDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
Mohan N ViswanathanDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
Tina BaykanerDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
Roy M JohnDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
Albert J RogersDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
Nitish BadhwarDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
Sanjiv M NarayanDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California; Cardiovascular Division, Cardiovascular Institute, Institute of Computational and Mathematical Engineering, Stanford University, Stanford, California.
Paul J WangDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
Marco V PerezDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California. Electronic address: mvperez@stanford.edu.

Funding

Machine Learning for Ventricular ArrhythmiasR01HL162260 · NHLBI · STANFORD UNIVERSITY · PI Sanjiv M Narayan · 2023 to 2026
$2.5M
Electrical Mapping Signatures of Adverse Structural and Functional Remodeling in Ventricular ArrhythmiaK23HL166977 · NHLBI · STANFORD UNIVERSITY · PI Albert Joseph Rogers · 2023 to 2026
$680k
NHLBI NIH HHS K23 HL166977NHLBI NIH HHS R01 HL162260
6 · The paper itself

Abstract

backgroundSubcutaneous implantable cardioverter-defibrillator ventricular fibrillation (VF) conversion testing success is influenced by implant geometry and shock impedance. Intermuscular (IM) generator placement reduces subgenerator adiposity, but coil-sternum distance remains a determinant of elevated high-voltage impedance.

objectiveThis study aimed to evaluate whether a combined strategy incorporating fluoroscopic skin marking, IM generator placement, and intraoperative ultrasound guidance (fluoroscopy-guided skin-marked IM implantation [FUSIM]) minimizes coil-sternum distance, lowers high-voltage shock impedance, and improves radiographic parameters vs conventional approaches.

methodsWe performed a retrospective single-center cohort study of adults undergoing subcutaneous implantable cardioverter-defibrillator implantation (January 1, 2014, to December 2024). Patients were grouped by technique: fluoroscopy-guided skin-marked subcutaneous implantation (SC), fluoroscopy-guided skin-marked IM implantation (FIM), and FUSIM. The primary endpoint was high-voltage shock impedance during VF conversion testing; analyses included group comparisons and multivariable logistic regression adjusted for body mass index. Radiographic measures were assessed in a consecutive single-operator subset.

resultsAmong 265 patients (age 41.2 ± 13.8 years; 36.2% female; SC n = 87; FIM n = 118; FUSIM n = 60), VF conversion testing was attempted in 214 (80.8%). High-voltage shock impedance was available in 186 patients, and quantitative radiographic measurements were available in 225. FUSIM was associated with lower impedance (60.9 ± 11.0 Ω) than SC (75.6 ± 19.1 Ω; P < .001) and FIM (70.9 ± 17.6 Ω; P < .01). An impedance of ≥70 Ω occurred in 19.5% (FUSIM), 39.7% (FIM), and 61.1% (SC). First-shock conversion failure at 65 J occurred in 3 of 214 (1.4%), all in the SC group. IM approaches had lower PRAETORIAN scores than SC, whereas the FUSIM group showed lower coil-sternum distance (P < .01).

conclusionFUSIM strategy was associated with lower high-voltage shock impedance and more favorable radiographic parameters. A prospective multicenter evaluation is warranted to determine whether FUSIM reduces the need for routine VF conversion testing.

Indexed as

Defibrillators, ImplantableProsthesis ImplantationSurgery, Computer-AssistedUltrasonography, InterventionalVentricular FibrillationAdultElectric ImpedanceFemaleFluoroscopyFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesDefibrillation threshold testingIntermuscular implantationPRAETORIAN scoreShock impedanceSubcutaneous implantable cardioverter-defibrillatorUltrasound guidance

Identifiers

PMID41921884
PMCPMC13275174

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.