Evidence map›Paper›PMID 41921604›Full record

ArticleNeuropharmacology2026

Anterior cingulate cortex activation of claustrum projection neuron subtypes is enhanced by alcohol.

Andreas B Wulff, Samuel H Sheats, Eliza A Douglass, Brian N Mathur

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andreas B WulffDepartment of Pharmacology and Physiology, School of Medicine, University of Maryland, Baltimore, MD, 21201, USA.
Samuel H SheatsDepartment of Pharmacology and Physiology, School of Medicine, University of Maryland, Baltimore, MD, 21201, USA.
Eliza A DouglassDepartment of Pharmacology and Physiology, School of Medicine, University of Maryland, Baltimore, MD, 21201, USA.
Brian N MathurDepartment of Pharmacology and Physiology, School of Medicine, University of Maryland, Baltimore, MD, 21201, USA; Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, MD, 21201, USA; University of Maryland Medicine Institute for Neuroscience Discovery, University of Maryland, Baltimore, MD, 21201, USA; Kahlert Institute for Addiction Medicine, University of Maryland, Baltimore, MD, 21201, USA. Electronic address: bmathur@som.umaryland.edu.

Funding

Striatal Microcircuit Dynamics of Ethanol HabitsR01AA024845 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI BRIAN NEIL MATHUR · 2016 to 2026
$3.9M
Synaptic Mechanisms of Nucleus Accumbens Disinhibition by EthanolR01AA028070 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI MATHUR, BRIAN NEIL · 2021 to 2025
$2.5M
Impact of Alcohol on Claustrum FunctionF32AA032136 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI Andreas Brydenfelt Wulff · 2024 to 2026
$234k
NIAAA NIH HHS F32 AA032136NIAAA NIH HHS R01 AA024845NIAAA NIH HHS R01 AA028070
6 · The paper itself

Abstract

Cognitive impairment is a major component of Alcohol Use Disorder. Optimal cognitive performance requires anterior cingulate input activation of the claustrum, a subcortical nucleus that orchestrates cortical activity. Yet the impact of chronic alcohol exposure on the ability for the anterior cingulate cortex to drive activity of claustrum projection neuron subtypes is unknown. In adult male and female mice, we found that the majority of non-burst firing Type 1 claustrum projection neurons did not express the vesicular glutamate transporter 2 (VGLUT2), while the majority of burst firing Type 2 projection neurons were VGLUT2-expressing. Following chronic intermittent vaporized ethanol exposure (CIE), we found that all claustrum neuron types exhibited increased responsivity to anterior cingulate cortex input activation. In Type 1 and VGLUT2-non-expressing neurons this was associated with increased postsynaptic membrane excitability. In contrast, Type 2 and VGLUT2-expressing projection neurons exhibited increased responsivity to anterior cingulate cortex input due to strengthened pre- and post-synaptic transmission mechanisms. Altogether, we uncovered a hyper-excitatory drive of the claustrum by the anterior cingulate cortex following chronic alcohol exposure. The data provide a foundational resource for the complex effects of chronic alcohol exposure on the claustrum, a critical cognitive control nucleus.

Indexed as

Central Nervous System DepressantsClaustrumEthanolGyrus CinguliNeuronsAnimalsFemaleMaleMiceMice, Inbred C57BLNeural PathwaysVesicular Glutamate Transport Protein 2Central Nervous System DepressantsEthanolVesicular Glutamate Transport Protein 2

Identifiers

PMID41921604
PMCPMC13353803

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.