ArticleLab on a chip2026
Rapid desiccation and on-disc rehydration of extracellular vesicles for non-cryogenic preservation.
Hyun-Kyung Woo, Sangjin Seo, Advitiya Mahajan, Seoyoung Lee, Seoyoon Bae, Jeremy M Quintana, Changhyun Kim, Alptekin Aksan, Hakho Lee
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In one paragraphArticle in Lab on a chip, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Hyun-Kyung WooCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, CPZN 5206, Boston, MA, USA. hlee@mgh.harvard.edu.
Sangjin SeoCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, CPZN 5206, Boston, MA, USA. hlee@mgh.harvard.edu.
Advitiya MahajanBiostabilization Laboratory, Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA. aaksan@umn.edu.
Seoyoung LeeCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, CPZN 5206, Boston, MA, USA. hlee@mgh.harvard.edu.
Seoyoon BaeCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, CPZN 5206, Boston, MA, USA. hlee@mgh.harvard.edu.
Jeremy M QuintanaCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, CPZN 5206, Boston, MA, USA. hlee@mgh.harvard.edu.ORCID 0000-0001-9820-1297 Changhyun KimDepartment of Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.
Alptekin AksanBiostabilization Laboratory, Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA. aaksan@umn.edu.ORCID 0000-0001-9891-1715 Hakho LeeCenter for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, CPZN 5206, Boston, MA, USA. hlee@mgh.harvard.edu.ORCID 0000-0002-0087-0909 Funding
Expanding early cancer detection with high throughput OCEANA - Ovarian Cancer Exosome Analysis with Nanoplasmonic ArrayU01CA284982 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Cesar M Castro, Hakho Lee · 2023 to 2026
$3.7MClinical platform for high-throughput analyses of extracellular vesiclesR01CA229777 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO, SKOG, JOHAN · 2018 to 2022
$3.2MImaging and Liquid Biopsy for Glioma Diagnosis and Treatment MonitoringR01CA239078 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BALAJ, LEONORA, LEE, HAKHO · 2020 to 2024
$3.1MHigh-throughput Phenotyping of iPSC-derived Airway Epithelium by Multiscale Machine Learning MicroscopyR01HL163513 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Hakho Lee, Kwonmoo Lee · 2023 to 2026
$3.1MComposing CODAs to cervical cancer screening through an integrated CRISPR and fluorescent nucleic acid approachU01CA279858 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Cesar M Castro, Hakho Lee · 2023 to 2026
$2.1M3D Fourier Imaging System for High Throughput Analyses of Cancer OrganoidsR21CA267222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO · 2022 to 2024
$613kStreamlining sample preparation with high throughput SpinEx (Separation processing integration for Extracellular vesicles)R61CA297878 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Hakho Lee · 2025 to 2026
$463kNCI NIH HHS R01 CA229777NCI NIH HHS R01 CA239078NCI NIH HHS R21 CA267222NCI NIH HHS R61 CA297878NCI NIH HHS U01 CA279858NCI NIH HHS U01 CA284982NHLBI NIH HHS R01 HL163513
6 · The paper itselfAbstract
Storage options for extracellular vesicles (EVs) remain limited, constraining their clinical and research applications. Conventional low-temperature freezing (-80 °C), although the established standard, requires substantial resources and presents logistical challenges. Here, we report an AridEx (Ambient Retention in Disc of Extracellular vesicles) approach for efficient room-temperature storage and recovery of EVs. AridEx leverages isothermal vitrification principles to preserve EVs, utilizing an electrospun trehalose-dextranol matrix as a xeroprotectant. The xeroprotectant matrix, combined with highly gas-permeable membranes, was integrated into a centrifugal microfluidic device, enabling the rapid desiccation of EV samples under mild vacuum conditions. The dried samples were stored directly on the disc at ambient temperature and subsequently recovered on demand
Indexed as
DesiccationExtracellular VesiclesMicrofluidic Analytical TechniquesHumansTrehaloseTrehalose
Identifiers
PMID41921558
PMCPMC13309737
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