ArticleOrganic letters2026
Ring-Enlargement of in Situ Generated Cyclopropanones with Carbonyls and Imines: Synthesis of γ-Butyrolactones and -lactams.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
We report a ring-enlargement of in situ generated cyclopropanones with aldehydes, ketones, and aldimines to access γ-butyrolactones and γ-lactams. Using bench-stable 1-sulfonylcyclopropanols as cyclopropanone precursors, the reaction proceeds under mild conditions and affords the products in yields of up to 84% across a range of carbonyl and imine coupling partners. Mechanistic experiments and DFT studies provide insight into the reaction pathway.
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