Evidence map›Paper›PMID 41921055›Full record

ArticleJournal of the American Chemical Society2026

Quantifying Protein Homodimer Affinities and the Effect of Molecular Glues and Interface Residues Using Native Mass Spectrometry.

Jonathan Schulte, Eric Schwegler, Ute A Hellmich, Nina Morgner

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jonathan SchulteInstitute of Physical and Theoretical Chemistry Goethe-University, Max-von-Laue-Str. 9, Frankfurt 60438, Germany.
Eric SchweglerFaculty of Chemistry and Earth Sciences Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich-Schiller-University, Jena 07743, Germany.
Ute A HellmichFaculty of Chemistry and Earth Sciences Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich-Schiller-University, Jena 07743, Germany.ORCID 0000-0001-7162-285X
Nina MorgnerInstitute of Physical and Theoretical Chemistry Goethe-University, Max-von-Laue-Str. 9, Frankfurt 60438, Germany.ORCID 0000-0002-1872-490X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological processes rely on finely tuned homo- and heteromeric interactions between (biomacro)molecules. The strength of an interaction, typically given by the dissociation constant (

Indexed as

Mass SpectrometrySerum Albumin, BovineAnimalsCattleProtein BindingProtein MultimerizationProtozoan ProteinsTrypanosoma brucei bruceiProtozoan ProteinsSerum Albumin, Bovine

Identifiers

PMID41921055
PMCPMC13088243

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.