ArticleScience advances2026
Reset-free DNA logic circuits for real-time input processing and memory.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
DNA logic circuits have great potential for biocompatible and programmable computations; however, current designs require reset processes, which restrict real-time data processing and memory functionality. This study proposes a reset-free approach on the basis of toehold-mediated chain reaction (TCR), which enables continuous and reversible strand migration within dual-rail units. By localizing TCR components on two-dimensional DNA origami templates, various combinational logic gates (e.g., AND and OR gates) and memory elements were implemented, including set-reset and data latches, as well as advanced cascaded registers. These circuits consistently processed new inputs and retained outputs over multiple sequential operations. The proposed reset-free TCR framework offers a mechanism most analogous to electronic circuit operation and demonstrates considerable potential for practical applications in biosensing, diagnostics, and synthetic biology.
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