Evidence map›Paper›PMID 41921002›Full record

ArticleScience advances2026

Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants.

Paula Berman, Janka Höfer, Herschel Mehlman, Efrat Almekias-Siegl, Olga Khersonsky, Younghui Dong, Uwe Heinig, Liron Sulimani, Let Kho Hao, Shahar Cohen and 6 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Reconstituting a two-step pathway forMetabolic engineering communications · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Paula BermanDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-6821-3307
Janka HöferDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0009-0005-8911-1325
Herschel MehlmanDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0009-0004-0314-0284
Efrat Almekias-SieglDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.
Olga KhersonskyDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-8065-2241
Younghui DongLife Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-0534-3868
Uwe HeinigLife Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
Liron SulimaniDepartment of Biology, Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0000-0003-1652-5920
Let Kho HaoDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.
Shahar CohenDepartment of Vegetable and Field Crops, Institute of Plant Sciences, Agricultural Research Organization (ARO), Volcani Center, Rishon LeZion, Israel.ORCID 0000-0003-0656-4627
Yoav PelegLife Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-0756-8788
Sagit MeirDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-7102-3152
Ilana RogachevDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-4452-2145
David MeiriDepartment of Biology, Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0000-0001-7627-1569
Sarel J FleishmanDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-3177-7560
Asaph AharoniDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-6077-1590

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychedelic indolethylamines with therapeutic potential are naturally produced in plants, fungi, and animals. Here, we elucidated the complete

Indexed as

Biosynthetic PathwaysHallucinogensPlantsTryptaminesBufoteninN,N-DimethyltryptaminePsilocybinBufoteninHallucinogensN,N-DimethyltryptaminepsilocinPsilocybinTryptamines

Identifiers

PMID41921002
PMCPMC13041772

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.