Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
37 authors.
Jialun ZhuInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0002-5241-3152
Xuanbing ChengInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0001-7682-0759
Mohammadreza BahramianInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0009-0000-5869-3194
Kuanming YaoInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0001-8744-8892
Zongqi LiInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0001-7608-4085
Bintao HuDepartment of Materials Science and Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.
Tsung-Yu WuInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0003-3880-6125
Kiarash A SabetInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0002-7911-4670
Jiarui CuiInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0009-0001-2528-9299
Jiawei TanInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0002-1394-5084
Junjie FangInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0009-0001-9168-967X
Yifu LiInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.
Connie HoInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0009-0006-6328-7098
Joshua NgInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0009-0001-6264-8641
Anthony SungInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0009-0008-0562-5903
Isabel RomeroDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0009-0003-5991-5299
Shuyu LinInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0002-5248-6124
Yichao ZhaoInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0002-2884-8105
Kaiji ZhangInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.
Ryan ChaiyakulInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0009-0007-9242-7771
Hanie YousefiDepartment of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-0127-7776
Jagotamoy DasDepartment of Chemistry, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-2724-1827
David JelinekDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0002-9234-311X
Laurent VoisinDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0003-2342-0596
Aaron AmbrusDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095,USA.
Ao ZhangDepartment of Materials Science and Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0002-9427-9641
Yitian ChiDepartment of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-0216-766X
Yu ChenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0009-0001-2693-1693
Chong LiuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-5546-3852
Hilary A CollerDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0003-0992-6494
Benjamin M WuDepartment of Materials Science and Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0001-5236-8534
Nanthia SuthanaDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-8796-3277
Shana O KelleyDepartment of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-3360-5359
Carlos MillaStanford Cystic Fibrosis Center, Center for Excellence in Pulmonary Biology, Stanford School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-5515-3053
Ira KurtzDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sam EmaminejadInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095,USA.ORCID 0000-0003-0132-152X
Funding
The Biology of NBCe1 in Health and DiseaseR01DK077162 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRA KURTZ · 2007 to 2026
$6.7M
Synchronized neuronal and peripheral biomarker recordings in freely moving humansR61MH135106 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NANTHIA W SUTHANA · 2024 to 2026
$3.1M
Reagentless Sensor Technologies For Continuous Monitoring of Heart Failure BiomarkersR01HL165002 · NHLBI · NORTHWESTERN UNIVERSITY · PI IGOR R EFIMOV, Shana O Kelley · 2023 to 2026
$3.0M
The Role of Stromal Autophagy in Cutaneous MelanomaR01CA221296 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLLER, HILARY A · 2018 to 2022
Wearable microneedle biosensors promise real-time molecular monitoring for precision medicine but are limited by low sensitivity and tissue abrasion. Overcoming these challenges, we recast electrode functionality not merely as a sensing substrate but as a mechanism for resilient, high signal-to-noise ratio (SNR) measurements in tissue. Our microneedle-based resilient nanostructured bioelectrode (RNB) is fabricated using a bilayer process that strengthens the electrode with a micrometer-thick gold adhesion layer and reduces fabrication-induced stress through controlled dealloying. The resulting RNBs are corrosion resistant, stable over a wide potential window, and have an artifact-free, nanocavity-textured interface. They integrate receptor-based electrochemical biosensors with enhanced SNR through increased active area, diffusion, and antifouling while remaining abrasion immune in megapascal-stiff tissues. The RNB extended in vivo biosensor lifetime for pharmacokinetics monitoring to 6 days in a freely moving rat. Paired with a blood-interstitial fluid equilibrium-based bioanalytical framework, the RNB accurately derived blood-equivalent pharmacokinetic parameters, enabling not only precision dosing of narrow therapeutic index drugs but also the direct assessment of hepatic and renal clearance. In hepatic studies, the RNB revealed delayed clearance of a chemotherapeutic (irinotecan) in liver-damaged models. In renal studies, RNB recordings correlated with blood antibiotic pharmacokinetics across chronic kidney disease severities. The RNB detected renal impairment earlier than conventional biomarker thresholds through drug clearance quantification and captured recovery under therapeutic intervention. These results establish the RNB as a viable microneedle platform for high-fidelity in vivo deployment of electrochemical biosensors, enabling minimally invasive, longitudinal monitoring of low-concentration analytes and real-time assessment of organ function.
Indexed as
KidneyLiverNanostructuresNeedlesAnimalsBiosensing TechniquesElectrodesMaleRatsRats, Sprague-DawleySignal-To-Noise Ratio
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Resilient nanostructured bioanalytic microneedle longitudinally monitors preclinical renal and hepatic drug clearance and dysfunction. · full record | OpenQuestion