ArticleJournal of AOAC International2026
Iridoid Glycosides as Key Discriminators of Cranberry (Vaccinium macrocarpon) Cultivars Revealed by UHPLC-HRAM-MSn Metabolomics.
Article in Journal of AOAC International, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCranberry (Vaccinium macrocarpon) contains diverse hydrophilic phytochemicals, but their compositional profiles and cultivar-specific variation have not been comprehensively characterized.
objectiveThe objective of this study was to profile hydrophilic metabolites in cranberry cultivars and identify constituents that differentiate among cultivars.
methodsWater-eluted fractions of Sephadex® LH-20-separated cranberry extracts from six cultivars (Crimson Queen, Demoranville, Haines, Mullica Queen, Stevens, and Welker) were analyzed using ultra-HPLC-high-resolution accurate-mass tandem mass spectrometry (UHPLC-HRAM-MSn). Metabolites were annotated based on accurate mass and MS2 fragmentation data and comparison with literature reports. Sparse partial least-squares discriminant analysis (sPLS-DA) was applied to assess classification performance and identify discriminative features.
resultsThirty-nine putative hydrophilic metabolites were identified, including hydroxycinnamic acid hexose derivatives, anthocyanins, hydroxycinnamoylquinic acids, and a distinct group of iridoid glycosides. Vaccinoside and several coumaroyl-substituted monotropein derivatives were structurally characterized in cranberry for the first time. sPLS-DA identified iridoid glycosides as key discriminators, with higher abundance observed in the Welker cultivar.
conclusionCranberry cultivars contain previously unreported iridoid glycosides that contribute to chemotaxonomic differentiation. These results expand current knowledge of cranberry hydrophilic phytochemistry and support the relevance of iridoid glycosides as cultivar-informative metabolites. HIGHLIGHTS: This study characterizes the highly polar, water-eluted fraction of six cranberry cultivars using UHPLC-HRAM-MSn analysis, resulting in the putative identification of 39 compounds, including a prominent series of iridoid glycosides.
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