ArticleProceedings of the National Academy of Sciences of the United States of America2026
Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Abstract
Electrocorticography (ECoG) provides a high-spatiotemporal-resolution measure of cortical activity (cortical surface electrical potentials, CSEPs) in humans and animals. The CSEP high-gamma band (Hγ, 65 to 170 Hz) correlates with neuronal firing rates at the columnar spatial scale and is widely used as a biomarker of local activity. Whether Hγ reports all stages of columnar processing, intermediate processing in L2/3 (close to the ECoG electrode), or the main columnar output in L5, is unknown. We disentangled the laminar origins of Hγ and other ECoG bands by optogenetically suppressing L2/3 or L5 pyramidal cells during micro-ECoG recording in the mouse somatosensory cortex. Whisker deflections evoked transient, topographically localized CSEPs. L5 optogenetic suppression most strongly reduced 65 to 450 Hz (Hγ-uHγ) bands in sensory-evoked ECoG signals, whereas L2/3 suppression most strongly reduced 4 to 27 Hz (θ-β) bands. Thus, different CSEP frequency bands reflect layer-specific activity and are biomarkers of distinct stages of sensory-evoked columnar processing.
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