Protocol for incomplete murine tumor resection to study local effects of surgical trauma on residual sarcoma.

Tyler R McCaw, Hy B Dao, Sin Yee Amelie Lim, Stuart A Fine, Michael S Shehata, Fritz C Eilber, Joseph G Crompton

Abstract read

In one paragraph

Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tyler R McCawDepartment of Surgery, Division of Surgical Oncology, University of California, Los Angeles, Los Angeles, CA, USA; Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA.

Hy B DaoDepartment of Surgery, Division of Surgical Oncology, University of California, Los Angeles, Los Angeles, CA, USA.

Sin Yee Amelie LimDepartment of Surgery, Division of Surgical Oncology, University of California, Los Angeles, Los Angeles, CA, USA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Stuart A FineDepartment of Surgery, Division of Surgical Oncology, University of California, Los Angeles, Los Angeles, CA, USA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Michael S ShehataOregon Health & Science University School of Medicine, Oregon Health & Science University, Portland, Portland, OR, USA.

Fritz C EilberDepartment of Surgery, Division of Surgical Oncology, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, Sarcoma Oncology Program, University of California, Los Angeles, Los Angeles, CA, USA.

Joseph G CromptonDepartment of Surgery, Division of Surgical Oncology, University of California, Los Angeles, Los Angeles, CA, USA; Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, Sarcoma Oncology Program, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: jcrompton@mednet.ucla.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncologic surgery aims to remove the entirety of cancer from a patient. However, we have little understanding of how surgical trauma impacts the residual primary tumor when disease is often left behind. Herein, we present a protocol to test the impact of surgical trauma on an incompletely resected murine sarcoma. We describe steps for tumor cell injection, tumor measurements, experimental group assignments, and maintaining sterility. We then detail procedures for surgical preparation, incision and tumor exposure, incomplete tumor resection, closure, and recovery.

Indexed as

Neoplasm, ResidualSarcomaAnimalsMiceCancerHealth SciencesModel Organisms

Identifiers

PMID41920743

DOI10.1016/j.xpro.2026.104481

PMCPMC13068815

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.