Evidence map›Paper›PMID 41920511›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2026

Energy metabolism reprogramming in Streptomyces mobaraensis driven by microparticles enhances transglutaminase production.

Tingting Chang, Luyao Bian, Chong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tingting ChangCollege of Food Science and Technology, Nanjing Agricultural University, 210095, Nanjing, P. R. China.
Luyao BianCollege of Food Science and Technology, Nanjing Agricultural University, 210095, Nanjing, P. R. China.
Chong ZhangGrain Storage, Transportation, Processing and Safety Engineering Research Center, Anhui Vocational College of Grain Engineering, 230011, Hefei, P. R. China. zhangchong@njau.edu.cn.ORCID http://orcid.org/0000-0002-7916-5136

Funding

Taixing Dongsheng Biotechnology Co., Ltd, China Grant No. HM0055
6 · The paper itself

Abstract

Although microparticle-enhanced cultivation (MPEC) significantly improves transglutaminase (TGase) yield, its underlying mechanism remains unclear. This study elucidated how talc and CaCO3 boost TGase production in Streptomyces mobaraensis HVCP-Sm1. Transcriptomic analysis revealed that both microparticles reprogram energy metabolism, but through distinct pathways: talc primarily enhanced energy conversion efficiency by activating ATP synthase and proton transmembrane transport, while CaCO3 augmented the supply of ATP and the substrate glutamine. Furthermore, overexpression of XDH-D (Gene 5232), encoding xanthine dehydrogenase subunit D, increased TGase titer by 39.4% to 21.24 U/mL. These findings demonstrate that talc and CaCO3 promote TGase synthesis by differentially rewiring central energy metabolism, and highlight the critical role of energy metabolic regulation in Streptomyces secondary metabolism.

Indexed as

Bacterial ProteinsEnergy MetabolismStreptomycesTransglutaminasesGene Expression ProfilingGene Expression Regulation, BacterialBacterial ProteinsTransglutaminasesEnergy metabolismGene overexpressionMicroparticle-enhanced cultivationStreptomyces mobaraensisTransglutaminase

Identifiers

PMID41920511
PMCPMC13043939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.