Evidence map›Paper›PMID 41920501›Full record

ArticlePharmacoEconomics2026

Utilization and Lifetime Costs of Formal Care for Alzheimer's Disease Dementia in Sweden.

Xin Xia, Maria Eriksdotter, Alice Clark, Niels Juul Brogaard, Jens Gundgaard, Pepa Polavieja, Nils Skajaa, Henrik Zetterberg, Silke Kern, Tobias Borgh Skillbäck and 1 more

Abstract read
In one paragraph

Article in PharmacoEconomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xin XiaDepartment of Neurobiology, Care Sciences and Society, Section for Neurogeriatrics, Karolinska Institutet, BioClinicum, Solnavägen 30, Floor 10, 171 64, Solna, Sweden. xin.xia@ki.se.ORCID http://orcid.org/0000-0002-8101-0563
Maria EriksdotterDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.
Alice ClarkNovo Nordisk A/S, Bagsvaerd, Denmark.
Niels Juul BrogaardNovo Nordisk A/S, Bagsvaerd, Denmark.
Jens GundgaardNovo Nordisk A/S, Bagsvaerd, Denmark.
Pepa PolaviejaNovo Nordisk A/S, Bagsvaerd, Denmark.
Nils SkajaaNovo Nordisk A/S, Bagsvaerd, Denmark.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Silke KernNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Tobias Borgh SkillbäckNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Linus JönssonDepartment of Neurobiology, Care Sciences and Society, Section for Neurogeriatrics, Karolinska Institutet, BioClinicum, Solnavägen 30, Floor 10, 171 64, Solna, Sweden.

Funding

AD Strategic Fund and the Alzheimer's Association ADSF-21-831376-CAD Strategic Fund and the Alzheimer's Association ADSF-21-831377-CAD Strategic Fund and the Alzheimer's Association ADSF-21-831381-CAD Strategic Fund and the Alzheimer's Association ADSF-24-1284328-CALF-agreement AF-939825ALF-agreement ALFGBG-1005471ALF-agreement ALFGBG-81392ALF-agreement ALFGBG-965923Alzheimerfonden AF-737641Alzheimerfonden AF-842471Alzheimerfonden AF-92995Alzheimerfonden AF-939825Alzheimer's Drug Discovery Foundation 201809-2016862European Union Joint Programme-Neurodegenerative Disease Research JPND2021-00694Innovative Health Initiative Joint Undertaking 101112145Novo Nordisk A/S KI 4-3128/2022Swedish Brain Foundation FO2024-0097Swedish Research Council 2019-02075Swedish Research Council 2019-02075_15Swedish Research Council 2019-02397Swedish Research Council 2022-01018Swedish Research Council 2023-00356Swedish Research Council 2024-03599Swedish State Support for Clinical Research ALFGBG-71320the European Partnership on Metrology, co-financed from the European Union's Horizon Europe Research and Innovation Programme and by the Participating States 22HLT07the European Union's Horizon 2020 research and innovation programme 860197the European Union's Horizon Europe research and innovation programme 101053962the National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, the UK Dementia Research Institute at UCL UKDRI-1003VINNOVA 2021-02680
6 · The paper itself

Abstract

introductionThe study aimed to estimate the utilization and lifetime costs of formal care for individuals with Alzheimer's disease (AD) dementia in Sweden.

methodsWe used longitudinal data from 20,366 individuals (mean age: 78.54 years) diagnosed with AD dementia from the Swedish Register of Cognitive/Dementia Disorders linked to other registers to derive data on formal care utilization, including inpatient and outpatient specialist care, prescribed drugs, and social care. We estimated formal care utilization across AD dementia stages defined by the Mini-Mental State Examination and the lifetime formal care costs (in 2023 Swedish krona, SEK) in patients with AD dementia using the Zhao and Tian estimator, which uses the inverse probability weighting technique to account for censoring due to loss to follow-up. The estimates of lifetime costs were compared with those of controls matched to patients with AD dementia by birth year, sex, and region of residence at the time of diagnosis.

resultsThe number of outpatient specialist visits decreased as AD severity increased, while the number of drug prescriptions and social care utilization increased with advancing AD stages. The estimated lifetime costs of formal care for AD dementia were 2,440,000 SEK (€212,174; $US230,189; 95% CI 2,088,000-2,793,000 SEK), compared with 510,000 SEK (€44,348; $US48,113; 95% CI 482,000-539,000 SEK) for matched controls.

conclusionsThis study estimated the utilization and lifetime costs of formal care for AD dementia using longitudinal register data. These findings will provide inputs for future economic evaluations of treatments and preventive interventions for AD dementia.

Indexed as

Alzheimer DiseaseHealth Care CostsAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleRegistriesSeverity of Illness IndexSweden

Identifiers

PMID41920501
PMCPMC13375677

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.