Predictive factors of upper gastrointestinal bleeding in children: a cross-sectional analysis.

Mehrnush Shams, Sanaz Mehrabani, Mohammad Reza Esmaili Dooki, Soraya Khafri

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Article in Wiener medizinische Wochenschrift (1946), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Mehrnush ShamsDepartment of Pediatrics, Faculty of Medicine, Babol University of Medical Sciences, Ganjafrooz Street, Babol, Mazandaran, Iran.

Sanaz MehrabaniDepartment of Pediatrics, Faculty of Medicine, Babol University of Medical Sciences, Ganjafrooz Street, Babol, Mazandaran, Iran. mehrabanisanaz@gmail.com.

Mohammad Reza Esmaili DookiDepartment of Pediatrics, Faculty of Medicine, Babol University of Medical Sciences, Ganjafrooz Street, Babol, Mazandaran, Iran.

Soraya KhafriDepartment of Biostatistics and Epidemiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

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6 · The paper itself

Abstract

backgroundUpper gastrointestinal bleeding (UGIB) in children presents diagnostic challenges. Geographic variations in etiology and the role of prolapse gastropathy as a distinct entity remain poorly characterized.

objectivesTo identify endoscopic findings and clinical predictors of pediatric UGIB, with an emphasis on prolapse gastropathy, and to develop a predictive model for risk stratification.

methodsThis cross-sectional study enrolled 100 children (aged 2 months to 17 years) with UGIB. Demographic, clinical, laboratory, and endoscopic data were collected. Univariate and multivariate logistic regression identified predictors.

resultsThe mean age of the children was 7.2 ± 4.1 years; 62% presented with hematemesis. In 41% of cases, the endoscopic findings were normal; prolapse gastropathy was the leading pathological finding (27%). Male gender was associated with prolapse gastropathy (OR = 3.87, p = 0.007); NSAID use predicted peptic ulcer (OR = 127.3, p < 0.001). Multivariate analysis identified abdominal pain (OR = 111.6, p < 0.001) and platelet count (p = 0.006) as independent predictors, with 97.0% model accuracy.

conclusionProlapse gastropathy represents the predominant pathological cause of UGIB in children. Male gender, abdominal pain, and platelet count are significant predictors enabling evidence-based risk stratification.

Indexed as

Gastrointestinal HemorrhageStomach DiseasesAbdominal PainAdolescentAnti-Inflammatory Agents, Non-SteroidalChildChild, PreschoolCross-Sectional StudiesEndoscopy, GastrointestinalFemaleHematemesisHumansInfantMalePlatelet CountProlapseAnti-Inflammatory Agents, Non-SteroidalClinical predictorsEndoscopic findingPediatric gastroenterologyPeptic ulcer diseaseProlapse gastropathy

Identifiers

PMID41920485

DOI10.1007/s10354-026-01137-8

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