Evidence map›Paper›PMID 41920419›Full record

ArticleAnnals of surgical oncology2026

Long-term Outcomes in Gallbladder Cancer Patients Treated with Curative-Intent Resection: Adjuvant Chemotherapy Versus Observation in a Multicenter Propensity Score-Matched Study.

Lin-Yi Yu, Zhi-Peng Liu, Hao-Ran Zhu, Yi Gong, Hai-Su Dai, Chao Yu, Zhao-Ping Wu, Wei Chen, Wei Guo, Ping Yue and 9 more

Abstract readMulticenter StudyComparative Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lin-Yi Yu *Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Zhi-Peng Liu *Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Hao-Ran Zhu *Department of Emergency Medicine, Southwest Hospital, Army Medical University, Chongqing, China.
Yi Gong *Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Hai-Su DaiDepartment of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Chao YuDepartment of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Zhao-Ping WuDepartment of Hepatopancreatobiliary Surgery, Jiujiang First People's Hospital, Jiujiang, China.
Wei ChenDepartment of Hepatopancreatobiliary Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Wei GuoDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Ping YueDepartment of General Surgery, First Affiliated Hospital of Lanzhou University, Lanzhou, China.
Dong ZhangDepartment of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Rui DingDepartment of Hepatopancreatobiliary Surgery, First Affiliated Hospital of Air Force Medical University, Xi'an, China.
Yi ZhuDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yan JiangDepartment of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Jie BaiDepartment of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Xian-Yu YinDepartment of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Tao QinDepartment of Hepatobiliary and Pancreatic Surgery, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China. goodfreecn@163.com.
Zhi-Yu ChenDepartment of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China. zhiyuchen@tmmu.edu.cn.
Hong-Ming LiuDepartment of Hepatobiliary Surgery, Daping Hospital, Army Medical University, Chongqing, China. liuhongming74@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to investigate the effects of adjuvant chemotherapy versus observation on recurrence and survival in patients treated with curative-intent resection for gallbladder cancer (GBC).

methodsWe selected consecutive GBC patients treated with curative-intent resection from a multicenter database between 2014 and 2021. The patients were subsequently divided into two groups: an observation group and a chemotherapy group. In the comparison analysis, propensity score matching was employed to adjust for potential confounding factors. The study endpoints were overall survival (OS) and progression-free survival (PFS). Event rates were estimated with Kaplan-Meier curves and compared via the log-rank test. The multivariable Cox regression model was used to identify factors independently associated with OS and PFS.

resultsA total of 604 GBC patients treated with curative-intent resection were included in this study, which were 511 in the observation group and 93 in the chemotherapy group. In the comparison between the chemotherapy group and the observation group, after propensity score matching, the 3-year OS rates and PFS rates were significantly higher in the chemotherapy group (n = 73) compared with the observation group (n = 188) after the 6 months. Among the 604 GBC patients, multivariable Cox regression analysis confirmed that chemotherapy was independently associated with better OS and PFS.

conclusionsAdjuvant chemotherapy following curative-intent resection for GBC can reduce the risk of recurrence and prolong survival.

Indexed as

CholecystectomyGallbladder NeoplasmsNeoplasm Recurrence, LocalWatchful WaitingAgedChemotherapy, AdjuvantFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisPropensity ScoreRetrospective StudiesSurvival RateAdjuvant chemotherapyGallbladder cancerOverall survivalProgression-free survivalPropensity score matching

Identifiers

PMID41920419

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.