ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026
Vancomycin: a dura damaging friend of the spine surgeon? An experimental study.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe aim of this experimental study was to better understand the impact of locally applied vancomycin on the dura mater.
methodsSpinal dura mater was extracted from cattle, sheep, and red deer and trimmed for the subsequent experimental purposes. Three different vancomycin concentrations of 1 mg/mL, 10 mg/mL, and 100 mg/mL were applied in a semi-open, self-constructed diffusion chamber. Protein quantitation and electrophoresis were performed to monitor proteins in the dura perfusates at different time points. High resolution liquid-chromatography mass spectrometry was performed for the measurement of time-dependent relative mass transfer of vancomycin at different time points.
resultsWhile previous results for a diffusion unlimited scenario utilizing second-harmonic generation microscopy (SHG) on dura mater thin sections showed concentration-dependent changes manifesting as tissue section swelling over time and a loss in SHG intensity (Schultz et al. (2025), Anal Chem acs.analchem.4c04887. https://doi.org/10.1021/acs.analchem.4c04887 ), our recent results on bulk tissue now revealed that vancomycin induced elevated protein loss. Specifically, protein release at a dosage of 10 mg/mL was notably higher than that in the cryo-control group (2-10 min). Our results showed that the relative mass transfer of vancomycin was greater (mean 3.9%) for the 1 mg/mL vancomycin experiment and the 10 mg/mL vancomycin experiment (mean 4.8%) compared to the 100 mg/mL vancomycin experiment (0.69%).
conclusionThrough biochemical analysis, our research provides novel perspectives on how different concentrations of vancomycin impact the dura mater. Our study demonstrates that vancomycin damages the dura by protein release and swelling.
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