Evidence map›Paper›PMID 41920308›Full record

ArticleAnnals of hematology2026

Infantile pyknocytosis: A rare but not so rare condition. A new case report.

Michela Ribersani, Alice Rubeo, Roberta Colletti, Daniela Regoli, Maria Grazia Nardacci, Walter Barberi, Giovanna Palumbo, Anna Maria Testi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Michela RibersaniHematology and Bone Marrow Transplantation Unit, Policlinico Umberto I, Sapienza University of Rome, Via Benevento 6, 00161, Rome, Italy. ribersani@bce.uniroma1.it.ORCID http://orcid.org/0000-0003-4281-4101
Alice RubeoPediatric Unit, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
Roberta CollettiDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Daniela RegoliMaternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Maria Grazia NardacciHematology and Bone Marrow Transplantation Unit, Policlinico Umberto I, Sapienza University of Rome, Via Benevento 6, 00161, Rome, Italy.
Walter BarberiHematology and Bone Marrow Transplantation Unit, Policlinico Umberto I, Sapienza University of Rome, Via Benevento 6, 00161, Rome, Italy.
Giovanna PalumboHematology and Bone Marrow Transplantation Unit, Policlinico Umberto I, Sapienza University of Rome, Via Benevento 6, 00161, Rome, Italy.
Anna Maria TestiDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-1354-3659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infantile pyknocytosis is a rare cause of neonatal jaundice associated with transient hemolytic and usually severe anemia, with a favorable outcome. Its etiology remains undetermined. The diagnosis is mainly based on the presence of abnormal erithrocytes (pyknocytes) on the peripheral blood smears. We report the description of a new case recently occurring in a 12-day old caucasian male. The newborn was submitted, together with his parents, to a complete diagnostic process including erithrocytes tests for osmotic resistance, membrane fragility and lysis, and the study of hemoglobin stucture. All the studies resulted compatible with the physiological state of the little patients and his parents. The aim of this paper, is to underline the importance of including this condition among the differential diagnostic hypotheses when dealing with a picture of neonatal hemolytic anemia.

Indexed as

Erythrocytes, AbnormalJaundice, NeonatalAnemia, HemolyticHumansInfant, NewbornMaleNewbornPyknocytosis; hemolytic anemia

Identifiers

PMID41920308
PMCPMC13043602

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