Isolation, total synthesis, and biological evaluation of dearomatized isoprenylated acylphloroglucinols from Hypericum przewalskii.

Yong Li, Fei-Fei Xiong, Xiao-Yang Sun, Xing-Ren Li, Dao-Feng Chen, Gang Xu, Yin Nian, Li-Dong Shao

Abstract read

In one paragraph

Article in Natural products and bioprospecting, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yong Li *Yunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China.

Fei-Fei Xiong *Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

Xiao-Yang Sun *Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

Xing-Ren LiKey Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

Dao-Feng ChenYunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China. dfchen@shmu.edu.cn.

Gang XuYunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China. xugang008@mail.kib.ac.cn.

Yin NianKey Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. nianyin@mail.kib.ac.cn.

Li-Dong ShaoYunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China. shaolidong@ynucm.edu.cn.ORCID http://orcid.org/0000-0003-4799-6784

Funding

Yunnan Key Laboratory Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan APR202301Yunnan Revitalization Talent Support Program Innovation Team Project 202305AS350014

6 · The paper itself

Abstract

New dearomatized isoprenylated acylphloroglucinols hyperprzewones A (1) and B (2) were isolated and characterized from the dried aerial parts of Hypericum przewalskii. The structures of these compounds were confirmed by extensive spectroscopic experiments. A facile synthetic route to 1 and 2 was developed via Friedel-Crafts acylation, alkylation, dearomatization, and oxidative [4 + 2] cyclization, giving a 17% overall yield. Moreover, the synthetic derivative 8 exhibited moderate inhibition on T-type calcium channels Ca

Indexed as

Dearomatized isoprenylated acylphloroglucinols (DIAPs)Hypericum przewalskiiTotal synthesisT-type calcium channels Cav3.2

Identifiers

PMID41920268

DOI10.1007/s13659-026-00626-y

PMCPMC13043971

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