Evidence map›Paper›PMID 41920262›Full record

Trial reportClinical oral investigations2026

Assessment of the effect of photodynamic therapy on the reduction of bacteria in deep dental caries lesions of primary teeth.

Sylwia Kuderewska, Łukasz Korczak, Piotr Majewski, Dominika Chludzińska, Paweł Sacha, Julia Kuźmiuk, Anna Kochańska, Elżbieta Tryniszewska, Grażyna Marczuk-Kolada

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sylwia KuderewskaDepartment of Pediatric Dentistry, Medical University of Bialystok, Bialystok, Poland. sylwia.kuderewska@umb.edu.pl.
Łukasz KorczakDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, Poland.
Piotr MajewskiDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, Poland.
Dominika ChludzińskaDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, Poland.
Paweł SachaDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, Poland.
Julia KuźmiukIndependent Public Healthcare Institution, Mińsk Mazowiecki, Poland.
Anna KochańskaDepartment of Pediatric Dentistry, Medical University of Bialystok, Bialystok, Poland.
Elżbieta TryniszewskaDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, Poland.
Grażyna Marczuk-KoladaDepartment of Pediatric Dentistry, Medical University of Bialystok, Bialystok, Poland.

Funding

Uniwersytet Medyczny w Bialymstoku B.SUB.23510/01.S
6 · The paper itself

Abstract

objectiveThe aim of the present study was to evaluate the effect of photodynamic therapy on the reduction of bacteria in deep carious lesions of primary teeth. MATERIALS AND

methodsThirty-six children presenting with deep carious lesions in primary molars were included in this randomized clinical study. After selective caries excavation, dentin samples were collected. Participants were randomly assigned to two groups according to the photosensitizer applied: 0.1% toluidine blue gel (FotoSan Agent® High) or curcumin QroxB2®. In both groups, aPDT was performed using the same diode lamp (FotoSan® 630; 630 nm) to ensure standardized clinical conditions. Dentin samples were collected before and after aPDT. Microbiological analysis was performed using conventional culture methods, and colony-forming units (CFU/ml) were quantified. Strain identification was performed using the VITEK® MS system (bioMérieux SSC, France).

resultsA statistically significant reduction in the total number of microorganisms was noted after therapy. A decrease in bacterial counts was also observed on selective media for total Streptococci and Streptococcus mutans. The degree of microbial reduction did not significantly differ depending on the photosensitizer used.

conclusionsWithin the limitations of this study, antimicrobial photodynamic therapy significantly reduced bacterial counts in deep carious lesions of primary teeth and may serve as an adjunctive method in selective caries excavation. CLINICAL SIGNIFICANCE: Photodynamic therapy may be used as an adjunct in selective caries excavation.

Indexed as

Dental CariesPhotochemotherapyPhotosensitizing AgentsTolonium ChlorideTooth, DeciduousChildChild, PreschoolColony Count, MicrobialCurcuminFemaleHumansMaleTreatment OutcomeCurcuminPhotosensitizing AgentsTolonium ChlorideDental cariesFotoSanPhotodynamic therapyPrimary teeth

Identifiers

PMID41920262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.