Evidence map›Paper›PMID 41920257›Full record

ArticleChinese journal of integrative medicine2026

Dihydroartemisinin Induces Ferroptosis in Ovarian Cancer via STAT3/GPX4 Signaling Pathway.

Lu Chen, You-You Li, Yue Xing, Lu-Yao Kang, Dan Lu

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Article in Chinese journal of integrative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Lu ChenDepartment of Gynaecology and Obstetrics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu Province, 225001, China. ludan1968@126.com.
You-You LiDepartment of Gynaecology and Obstetrics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu Province, 225001, China.
Yue XingDepartment of Gynaecology and Obstetrics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu Province, 225001, China.
Lu-Yao KangDepartment of Gynaecology and Obstetrics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu Province, 225001, China.
Dan LuDepartment of Gynaecology and Obstetrics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu Province, 225001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects and underlying mechanism of action of dihydroartemisinin (DHA) on ferroptosis in ovarian cancer (OC).

methodsIn vitro, SKOV3 and A2780 cells were treated with different concentrations of DHA. The proliferative capacity of DHA-treated OC cells was determined using cell counting kit-8 assay, scratch test and clone formation assay. In addition, OC cells were treated with the ferroptosis inhibitor (ferrostatin-1; Fer-1) in combination with DHA to observe the changes in cell viability. To confirm the oxidative stress-inducing effect of DHA, levels of Fe

resultsDHA significantly reduced the viability of OC cells, and treatment with Fer-1 significantly increased the survival rate of OC cells (P<0.05 or P<0.01). Subsequent to the administration of DHA, the migration rate and clone formation ability of OC cells decreased significantly (P<0.01). Compared with control cells, DHA-treated OC cells exhibited increased Fe

conclusionTreatment with DHA can inhibit OC cell proliferation and induce ferroptosis in OC, and these effects may be predominantly mediated via STAT3/GPX4 signaling pathway.

Indexed as

ArtemisininsFerroptosisOvarian NeoplasmsPhospholipid Hydroperoxide Glutathione PeroxidaseSignal TransductionSTAT3 Transcription FactorAmino Acid Transport System y+AnimalsCell Line, TumorCell ProliferationCell SurvivalFemaleGene Expression Regulation, NeoplasticGlutathioneHumansMiceAmino Acid Transport System y+ArtemisininsartenimolGlutathionePhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesSTAT3 protein, humanSTAT3 Transcription FactorChinese medicinedihydroartemisininferroptosisovarian cancerSTAT3/GPX4 axis

Identifiers

PMID41920257

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.